文献类型：期刊文献

英文题名：Study on the Preparation of Quaternized Chitosan/Agarose Microspheres for Berbamine Delivery

作者：Hu, Zhang[1];Hong, Peng-Zhi[1];Li, Si-Dong[1];Yang, Lei[1];Xie, Jian-Ying[1]

机构：[1]Guangdong Ocean Univ, Coll Sci, Zhanjiang 524088, Peoples R China

年份：2012

卷号：29

期号：3

起止页码：361

外文期刊名：JOURNAL OF POLYMER MATERIALS

收录：SCI-EXPANDED(收录号：WOS:000313310900008)、、Scopus(收录号：2-s2.0-84873393201)、WOS

基金：This work was supported by the Program for Excellent Talents in Guangdong Ocean University (Grant no. 0912118).

语种：英文

外文关键词：Quaternized chitosan; agarose; microspheres; berbamine

外文摘要：Berbamine loaded quaternized chitosan/agarose microspheres were prepared using a water-in-oil emulsion technique. Optimum preparing parameters were determined by orthogonal experiments as follows: ratio of berbamine to quaternized chitosan (w/w), 1:10; percentage of emulsifier (span 80, v/v), 1%; volume of glutaraldehyde, 3 mL; and reaction temperature, 70 degrees C. Under these optimal conditions, the encapsulation efficiency and loading capacity of microspheres are 86.01% and 7.52%, respectively. Swelling test showed that the microspheres possessed higher swelling ratio at pH 7.4 than at pH 1.2. FTIR indicated that berbamine had been successfully loaded in the quaternized chitosan/agarose microspheres by physical entrapment. In vitro release studies showed that berbamine was released from microspheres in a significantly sustained fashion.