文献类型：期刊文献

英文题名：Lanthanide-doped mesoporous MCM-41 nanoparticles as a novel optical-magnetic multifunctional nanobioprobe

作者：Liu, Jun[1,2,3];Liu, Siqian[1,2];Li, Yaling[1,2];Xue, Jiayan[1,2];He, Youyi[1,2];Liu, Fuchi[1,2];Yang, Li[1,2];Hu, Junhui[1,2];Xiong, Zhengye[4];Long, Lizhen[1,2]

机构：[1]Guangxi Normal Univ, Coll Phys Sci & Technol, Guilin 541004, Peoples R China;[2]Guangxi Normal Univ, Guangxi Key Lab Nucl Phys & Technol, Guilin 541004, Peoples R China;[3]State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China;[4]Guangdong Ocean Univ, Sch Elect & Informat Engn, Zhanjiang 524088, Peoples R China

年份：2019

卷号：9

期号：70

起止页码：40835

外文期刊名：RSC ADVANCES

收录：SCI-EXPANDED(收录号：WOS:000510247900008)、、EI(收录号：20195107885929)、Scopus(收录号：2-s2.0-85076707390)、WOS

基金：This work was supported by the Natural Science Foundation of Guangxi (No. 2018GXNSFBA138007, 2018GXNSFBA281073, 2018GXNSFAA294021), the National Natural Science Foundation of China (No. 11665007, 11664003), the Guangxi Key Research and Development Program (No. AB18221033), the State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B11), the PhD Start-up Fund of Guangxi Normal University (No. 2017BQ023, 2017BQ006), and the Innovation Project of Guangxi Graduate Education (No. XYCSZ2019058).

语种：英文

外文关键词：Photoluminescence - Pore structure - Targeted drug delivery - Silica nanoparticles - Sol-gels - Nanoprobes - Nanomagnetics - Sol-gel process - Bioimaging - Controlled drug delivery - Optical properties - Synthesis (chemical)

外文摘要：To research and develop potential multifunctional nanoprobes for biological application, lanthanide-doped MCM-41 (Ln-MCM-41, Ln = Gd/Eu) silica nanoparticles with excellent pore structure and optical-magnetic properties were synthesized via a facile and economical sol-gel method. The microstructure and pore distribution of Ln-MCM-41 nanoparticles were obviously affected by the Ln-doping. As the Ln/Si mole ratio increased, the specific surface area and total pore volume of Ln-MCM-41 nanoparticles rapidly decreased. However, the Ln-MCM-41 nanoparticles still retained the typical well-ordered mesoporous structure, and exhibited excellent drug release behavior. Moreover, the drug release rate of Ln-MCM-41 was remarkably pH-dependent and increased gradually upon decreasing pH. Additionally, these nanoparticles also exhibit considerable photoluminescence properties, living cells photoluminescence imaging in vitro, and paramagnetism behavior at room temperature due to the Ln(3+)-ions doping. Our research shows the possibility of our Ln-MCM-41 nanoparticles as multifunctional nanoprobes for application in bioseparation, bioimaging, and drug delivery.