文献类型：期刊文献

英文题名：Development of a cobalt (II) and 1,10-phenanthroline carboxaldehyde-based fluorescent probe for the detection of cysteine

作者：Zhang, Haoshun[1];Lan, Peiyu[2];Yang, Qinnan[2];Li, Ciling[3];Zhao, Liting[3];Kang, Xinhuang[3];Li, Yubin[3,4]

机构：[1]Guangdong Ocean Univ, Fac Oceanog & Meteorol, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Fac Food Sci & Technol, Zhanjiang 524088, Peoples R China;[3]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[4]Guangdong Ocean Univ, Res Ctr Coastal Environm Protect & Ecol Resilience, Zhanjiang 524088, Peoples R China

年份：2023

卷号：101

期号：10

起止页码：821

外文期刊名：CANADIAN JOURNAL OF CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001010007200001)、、EI(收录号：20234414987669)、Scopus(收录号：2-s2.0-85175033989)、WOS

基金：This work was supported by the project of Guangdong Natural Science Foundation, China (2023A1515011157), the Foundation And Applied Foundation Research Joint-Youth Fund project of Guangdong Province, China (2019A1515110648), the project of Enhancing School with Innovation of Guangdong Ocean University, China (2020KZDZX1108), Zhanjiang Key Laboratory of Comprehensive Utilization of Chemical Research for Marine Resources (A14457), and Zhanjiang Key Laboratory of Marine Bio-Materials Research (A15445). We would like to thank Editage (www.editage.cn) for English language editing.

语种：英文

外文关键词：cysteine; Co complex; fluorescent probes; sensor

外文摘要：Effective cysteine (Cys) detection is extremely important for early disease monitoring and diagnosis. In this study, a fluorescent probe (PHO) comprising 1,10-phenanthroline carboxaldehyde as the ligand and cobalt as the central ion was synthesized to detect Cys. The synthesized PHO exhibited enhanced fluorescence at 603 nm in the presence of Cys in HEPES buffer. Furthermore, the probe detected Cys concentrations as low as 0.6 mu mol/L, demonstrating high sensitivity. Additionally, a strong linear relationship was established between the Cys concentration and normalized intensity of fluorescence. Importantly, the high selectivity was retained even in the presence of other interfering compounds. Consequently, this method can serve as a novel approach for detecting Cys in physiological systems.