文献类型：期刊文献

英文题名：The evaluation of catechins reducing heterocyclic aromatic amine formation: Structure-activity relationship and mechanism speculation

作者：Xie, Ruiwei[1];Zhang, Haolin[1,2];Lv, Xiaomei[1];Lin, Qiuyi[1];Chen, Bing-Huei[3];Lai, Yu-Wen[3];Chen, Lei[1];Teng, Hui[1];Cao, Hui[1]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Guangdong Prov Engn Lab Marine Biol Prod, Zhanjiang 524088, Peoples R China;[2]Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China;[3]Fu Jen Catholic Univ, Dept Food Sci, New Taipei City 24205, Taiwan

年份：2024

卷号：8

外文期刊名：CURRENT RESEARCH IN FOOD SCIENCE

收录：SCI-EXPANDED(收录号：WOS:001219636100001)、、WOS

基金：The present work was supported by National Natural Science Foundation of China (NSFC, Grant No. 32061160477, 31972072, 32272315) .

语种：英文

外文关键词：Chemical model; PhIP; MeIQx; Mechanism; Phenylacetaldehyde; EGCG

外文摘要：The favorable inhibitory effect of tea polyphenols on heterocyclic aromatic amines (HAAs) has been confirmed in many past studies. The objective of this study was to investigate the structure-activity relationship of catechins that act as inhibitors of HAA formation in chemical models. Two kinds of quantitative structure-activity relationship models for catechin-inhibiting-HAA were established. We chose two kinds of HAAs including 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), and five catechins including epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC), epicatechin (EC), and catechin (C). The inhibitory effect of five catechins were in the following order: EGCG > ECG > EGC > C > EC. Thereinto, EGCG and ECG showed dramatically better inhibition on the formation of PhIP and MeIQx, especially EGCG. Further, the mechanisms of catechin-inhibiting-HAA were speculated by correlation analysis. The free radical-scavenging ability was predicted to be the most relevant to the inhibitory effect of ECG, EGC, EC and C on HAAs. Differently, the phenylacetaldehyde-trapping ability might be the more important mechanism of EGCG inhibiting PhIP in chemical model system. This study may bring a broader idea for controlling the formation of HAAs according to the structure of catechins.