文献类型：期刊文献

英文题名：Dietary supplementation with casein/cyanidin-3-O-glucoside nanoparticles alters the gut microbiota in high-fat fed C57BL/6 mice

作者：Lyu, Qiyan[1];Deng, Hongting[1];Wang, Shunxin[1];El-Seedi, Hesham[2];Cao, Hui[1];Chen, Lei[1];Teng, Hui[1]

机构：[1]Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Guangdong Prov Engn Lab Marine Biol Prod, Guangdong Prov Engn Technol Res Ctr Seafood,Key La, Zhanjiang 524088, Peoples R China;[2]Uppsala Univ, Biomed Ctr, Dept Med Chem, Pharmacognosy Grp, Box 574, S-75123 Uppsala, Sweden

年份：2023

卷号：412

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000963681900001)、、EI(收录号：20230613539793)、Scopus(收录号：2-s2.0-85147192157)、WOS

基金：This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 32272315, 32072209) , the Natural Science Foundation of Guangdong Province (2022A1515010694) , China Post- doctoral Science Foundation Funded Project (2020M682073) , the Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) .

语种：英文

外文关键词：Cyanidin-3-O-glucoside; Nanoparticles; High -fat -diet; Gut microbiota

外文摘要：This study aims to investigate the dietary intervention effect of casein/cyanidin-3-O-glucoside nanoparticles (CsC3G) on high-fat-diet (HFD)induced gut microbiota disorders. In HFD-fed C57BL/6mice, Cs-C3G has ameliorated HFD-caused fat accumulation and liver oxidative stress. Cs-C3G as a dietary supplementation can restore the abundance and diversity of gut microbiota with descending the ratio of Firmicutes to Bacteroidetes, increasing some beneficial microorganisms, and reducing some opportunistic pathogenic bacteria. In general, Cs-C3G has a effect on regulating the disturbance of gut microbiota, and then prevents HFD-induced obesity and liver damage.