文献类型：期刊文献

英文题名：Septin 2: A direct target of Ginsenoside Rg1 mediating its neuroprotective effects

作者：Li, Jun[1,2];Zhou, Jie-Chun[1,3];Wen, Wei-Ping[1];Zhou, Yu[1];Li, Hui-Lin[1];He, Shu-Jie[1];Liu, Yu-Ting[1];Yang, Zhi-You[4];Piao, Xiu-Hong[5];Wang, Shu-Mei[1];Yu, Jie[2];Ge, Yue-Wei[1,2]

机构：[1]Guangdong Pharmaceut Univ, Sch Chinese Mat Med, Key Lab Digital Qual Evaluat Chinese Mat Med State, Guangzhou 510006, Peoples R China;[2]Yunnan Univ Chinese Med, Yunnan Key Lab Southern Med Utilizat, Kunming 650500, Peoples R China;[3]Nanfang Coll Guangzhou, Guangzhou 510970, Peoples R China;[4]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[5]Guangdong Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Guangzhou 510006, Peoples R China

年份：2026

卷号：245

外文期刊名：BIOCHEMICAL PHARMACOLOGY

收录：SCI-EXPANDED(收录号：WOS:001651439000001)、、Scopus(收录号：2-s2.0-105025416863)、WOS

基金：This research work was supported by the National Key Research and Development Program of China (No. 2023YFC3504000, China); the Guangdong Basic and Applied Basic Research Foundation (No. 2024A1515012250, China); Innovative Team Project of Universities in Guangdong Province (No. 2023KCXTD020, China); Yunnan Science and Technology Talent and Platform Program (No. 202105AG070012, China); and the National Natural Science Foundation of China (No. 81872988 and 82074117, China).

语种：英文

外文关键词：Alzheimer's disease; Ginsenoside Rg1; Neuroprotection; Target; DARTS

外文摘要：Ginsenoside Rg1 (Rg1), a representative saponin of ginseng, is evidenced with a remarkable neuroprotective effect; however, its direct target in neural cells has not been addressed. The present study investigated the reconstructing effect on the damaged neurite network of Rg1, and its direct target responsible for this bio-effect. The results showed that Rg1 can alleviate the A beta 25-35-induced neuronal damage and synaptic atrophy in primary neurons and PC12 cell models, respectively. Furthermore, the Septin 2, involved in cell division and cytoskeleton organization, was identified as a protein specifically binding to Rg1. In addition, the overexpression and knockdown of Septin 2 in PC12 cells supported its role in mediating the neural protective effect of Rg1. These findings uncover Septin 2 as a key target of Rg1 in neural cells, which also provides insight into the intervention mechanism of ginseng in neurological disorders.