文献类型：期刊文献

英文题名：Threonine Facilitates Cd Excretion by Increasing the Abundance of Gut Escherichia coli in Cd-Exposed Mice

作者：Li, Yongbin[1];Fang, Zhijia[1];Zhou, Xuewei[1];Gao, Jian[2];Wang, Jingwen[1];Huang, Linru[1];Chen, Yinyan[1];Sun, Lijun[1];Deng, Qi[1];Gooneratne, Ravi[3]

机构：[1]Guangdong Ocean Univ, Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Coll Food Sci & Technol, Res Ctr Marine Food,Guangdong Prov Key Lab Aquat P, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Continuing Educ, Zhanjiang 524088, Peoples R China;[3]Lincoln Univ, Dept Wine Food & Mol Biosci, Lincoln 7647, Canterbury, New Zealand

年份：2023

卷号：28

期号：1

外文期刊名：MOLECULES

收录：SCI-EXPANDED(收录号：WOS:000908898300001)、、Scopus(收录号：2-s2.0-85145749551)、WOS

基金：This work was supported by the National Natural Science Foundation of China (Nos. 32172215 and 31701706), the Natural Science Foundation of Guangdong Province (Nos. 2019A1515010809 and 2021A1515012443), the Characteristic Innovation Project of Guangdong Province (No. 2018KTSCX089) and the Program for Scientific Research Start-up Funds of the Guangdong Ocean University (Nos. R17102 and 060302042008).

语种：英文

外文关键词：cadmium; amino acids; threonine; Escherichia coli; gut microbiota

外文摘要：Cadmium (Cd) can easily enter the body through the food chain and threaten health since Cd pollution is prevalent in the environment. Gut microbiota is necessary for the reduction of metal ions. To reduce Cd-induced harmful impacts and Cd accumulation in the body, we investigated the effect of amino acids on gut microbiota and Cd excretion in (fecal Cd) Cd-exposed mice. The screening of 20 amino acids showed that threonine (Thr) effectively increased fecal Cd, and reduced Cd-induced intestinal structural damage. The abundance of Escherichia-Shigella genus and KF843036_g significantly increased after the oral administration of Thr. As the type species of the Escherichia-Shigella genus, Escherichia coli exhibited high similarity to KF843036_g species and significantly decreased Cd-induced gut damage. Cd contents in the liver, kidney, and gut of Cd-exposed mice were also significantly (p < 0.05) decreased after E. coli treatment, while the contents in the feces were increased. The results demonstrated the potential roles that gut E. coli might play in Thr-mediated Cd excretion in Cd-exposed mice. The findings may provide important data for better understanding the molecular biological mechanism of Thr in reducing Cd accumulation in the body.