文献类型：期刊文献

英文题名：Effects of bisphenols on lipid metabolism and neuro-cardiovascular toxicity in marine medaka larvae

作者：Li, Xueyou[1,2];He, Xiaoxu[4];Lin, Xiaona[1];Li, Weihao[1];Gao, Jiahao[1];Zhang, Ning[1];Guo, Yusong[1];Wang, Zhongduo[1];Zhao, Na[1,3];Zhang, Bo[1,3,4];Dong, Zhongdian[1,2]

机构：[1]Guangdong Ocean Univ, Guangdong Higher Educ Inst, Coll Fishery, Key Lab Aquaculture South China Sea Aquat Econ Ani, Zhanjiang, Peoples R China;[2]Guangdong Ocean Univ, Coll Fishery, Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Zhanjiang, Peoples R China;[3]Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang, Peoples R China;[4]Tianjin Fisheries Res Inst, Tianjin 300200, Peoples R China

年份：2023

卷号：259

外文期刊名：AQUATIC TOXICOLOGY

收录：SCI-EXPANDED(收录号：WOS:001001269700001)、、Scopus(收录号：2-s2.0-85157982368)、WOS

基金：This research was financed by the National Natural Science Foundation of China (41806195, 41907346, 31972794) , Special Innovation Projects of Colleges and Universities in Guangdong Province (2018KTSCX087, 2018KQNCX110) , Nanhai Scholar Project of GDOU (QNXZ201807, 201903) , and Postgraduate Education Innovation Project of Guangdong Ocean University (202154) .

语种：英文

外文关键词：bisphenols; lipid metabolism; Oryzias melastigna

外文摘要：Bisphenols are environmental endocrine disruptors that have detrimental effects on aquatic organisms. Using marine medaka larvae, this study explored the effects of bisphenol compounds [bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF)] on the early growth and development of aquatic organisms. Marine medaka larvae were exposed to bisphenol compounds at concentrations of 0.05, 0.5, and 5 mu M for 72 h, and changes in heartbeat rate, behavior, hormone levels, and gene expression were determined. Bisphenols were shown to have a toxic effect on the cardiovascular system of larvae and can cause neurotoxicity and endocrine disruption, such as changes to thyroid-related hormones. Functional enrichment showed that bisphenols mainly affect lipid metabolism and cardiac muscle contraction of larvae, which implied that the main toxic effects of bisphenols on marine medaka larvae targeted the liver and heart. This study provides a theoretical foundation for evaluating the toxicological effects of bisphenols on the early development of aquatic organisms.