文献类型：期刊文献

中文题名：海红米米糠对慢性应激诱导小鼠抑郁样行为和异常肠道微生物及神经递质的改善作用

英文题名：Sea Red Rice Bran Improved Depression-Like Behavior,Abnormal Gut Microbes and Monoamine Neurotransmitters Induced by Chronic Unpredictable Mild Stress

作者：李晓红[1,4];Rabia Parveen[1];杨志友[1];张永平[1];周鸿凯[3];刘文超[3];苏伟明[2];宋采[1,4]

机构：[1]广东海洋大学食品科技学院,湛江524088;[2]广东省水产品加工与安全重点实验室,湛江524088;[3]广东海洋大学滨海农业学院,湛江524088;[4]广东海洋大学深圳研究院,深圳518120

年份：2022

卷号：37

期号：3

起止页码：25

中文期刊名：中国粮油学报

外文期刊名：Journal of the Chinese Cereals and Oils Association

收录：CSTPCD、、CSCD2021_2022、Scopus、北大核心、CSCD、北大核心2020

基金：广东省促进经济发展专项资金(粤自然资源合[2019]015号);深圳大鹏新区产业发展专项(KY20180201);广东海洋大学创新强校工程(GDOU2013050102,230420022)。

语种：中文

中文关键词：抑郁;海红米米糠;慢性不可预见温和应激;肠道菌群;单胺类神经递质

外文关键词：depression;sea red rice bran;chronic unpredictable mild stress;gut microbes;monoamine neurotransmitters

中文摘要：“微生物-肠-脑轴”失常在抑郁症的发病中发挥着重要作用,调节肠道菌群失衡成为最新的治疗方向。海红米米糠可发挥益生元作用调控肠道微生物。为探究海红米米糠改善慢性不可预测温和应激(CUMS)诱导的小鼠抑郁样行为的作用。对照和暴露于CUMS的小鼠接受正常或含5%海红米米糠饮食喂养9周,通过糖水偏好实验和悬尾实验分析小鼠的抑郁样行为,实时荧光定量PCR法检测结肠内容物菌群的数量,HPLC测定前额皮层中单胺类神经递质的含量。应激使小鼠糖水偏好度、乳杆菌属和双歧杆菌属的数量、去甲肾上腺素(NE)与其代谢产物、五羟色胺(5-HT)与其代谢产物、多巴胺(DA)与其代谢产物的含量都显著下降,悬尾不动时间和梭菌属的数量都显著升高;海红米米糠干预后提高了小鼠的糖水偏好度、乳杆菌属和双歧杆菌属的数量、5-HT与其代谢产物和NE的含量,降低了悬尾不动时间。海红米米糠改善CUMS诱导的小鼠抑郁样行为可能与改善肠道菌群失衡及神经递质有关。

外文摘要：Abnormal “Gut-Brain axis” plays an important role in the etiology of depression.Hence, normalization of intestinal microbes has become a new treatment direction. Because sea red rice bran(SRRB) can play a prebiotic role in regulating intestinal microbes. The aim of the present study was to explore the effect of SRRB on improving depression-like behaviors in mouse model of depression induced by chronic unpredictable mild stress(CUMS). Control and CUMS-exposed mice were fed normal or 5% SRRB diet for 9 weeks. Sucrose preference and tail suspension tests were performed to analyze depression-like behaviors. Detecting the population of colonic flora by Real-time fluorescence quantitative PCR. Concentrations of monoamine neurotransmitters in the prefrontal cortex were detected by HPLC. CUMS significantly decreased sucrose preference and the population of Lactobacillus and Bifidobacterium, while significantly increased immobility time. In addition, CUMS decreased the concentrations of noradrenalin(NE) and its metabolites, serotonin(5-HT) and its metabolites, dopamine(DA) and its metabolites and increased the population of Clostridium. SRRB could significantly increase sucrose preference, the population of Lactobacillus and Bifidobacterium, the content of NE, 5-HT and its metabolites, while reduce immobility time. SRRB improved CUMS-induced depression-like behavioral changes may be through normalizing homeostasis of gut microbes and neurotransmitters.