文献类型：期刊文献

英文题名：Antisolvent Sequence as a Tunable Switch for Zein-Naringin-TPGS Nanoparticles: Interfacial Dynamics and Bioactivity Enhancement

作者：Wang, Yitong[1,2]; Qiu, Keyu[1,2]; Zhou, Ruizi[1,2]; Bai, Shuxian[1]; Ai, Chao[1,2]; Zhao, Yanan[1,2]; Simal-Gandara, Jesus[1,3]; Teng, Hui[1,2]; Chen, Lei[1,2]

机构：[1] College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang, 524088, China; [2] Shenzhen Institute of Guangdong Ocean University, Shenzhen, 518108, China; [3] University of Vigo, Spain

年份：2025

外文期刊名：SSRN

收录：EI(收录号：20250487204)

语种：英文

外文关键词：Antioxidants - Bioactivity - Encapsulation - Hydrogen bonds - Plants (botany)

外文摘要：The aim of this study was to form different type nanoparticles by zein, TPGS and NRG, nanoparticles were obtained by the anti-solvent method, and to analyze the internal interaction forces, stability and antioxidative. The sequence of the antisolvents used becomes the primary factor influencing the properties of the nanoparticles. Nanoparticles were characterized by multimodal analysis, as spectroscopy, molecular docking, SEM, XRD, FTIR, TGA, and ITC. NRG is stabilized within the zein matrix through hydrogen bonding involving Gln residues and hydroxyl or carbonyl groups, coupled with hydrophobic sequestration of its aglycone moiety in Pro-rich nonpolar cavities. The encapsulation efficiency of NRG increased up to 72.71% at (Z-N)-T, which is the highest stability among different types of nanoparticles. The nanoparticles average size below 105 nm, and the zeta potential is 25.48 mV, and also exhibits significant antioxidant activity. ? 2025, The Authors. All rights reserved.