文献类型：期刊文献

英文题名：Effect of curcumin supplementation on TLR4 mediated non-specific immune responses in liver of laying hens under high-temperature conditions

作者：Nawab, Aamir[1];Li, Guanghui[1];An, Lilong[1];Wu, Jiang[1];Chao, Liuwen[1];Xiao, Mei[1];Zhao, Yi[1];Birmani, Muhammad Waseem[1];Ghani, Muhammad Waseem[1]

机构：[1]Guangdong Ocean Univ, Agr Coll, Dept Anim Sci, Haida Rd, Zhanjiang 524088, Guangdong, Peoples R China

年份：2019

卷号：84

起止页码：384

外文期刊名：JOURNAL OF THERMAL BIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000486107400045)、、Scopus(收录号：2-s2.0-85071764461)、WOS

基金：Special thanks to Journal of Thermal Biology for giving opportunity to share knowledge on the effect of curcumin supplementation on TLR4 mediated non-specific immune responses in liver of laying hens under high-temperature conditions which will be helpful for readers. The author wishes to thank teachers, parents (Rana Nawab Ahmad and Mrs. R Sultana), uncle (RanaMaqbool Ahmad) for continued support and excellent mentorship. This work was supported by Science and Technology Planning Project of Guangdong Province, China (2010 B090400376).

语种：英文

外文关键词：Anti-inflammatory; Antioxidant; Curcumin; Heat stress; Laying hen; Oxidative damage

外文摘要：The liver performs a significant role in innate and adaptive immunity. Heat stress causes oxidative stress in liver tissues and reduces the immune responses of laying hens which can cause several diseases affecting poultry-production performance. Hepatic inflammation is a common trigger of liver disease, which is reflected by hepatic tissue damage leading to fibrogenesis and hepatocellular carcinoma. Dietary manipulation of curcumin has been proposed to ameliorate the immune status of chickens under heat stress. Thus, this study aimed to investigate the effect of curcumin supplementation on TLR4 mediated non-specific immune response in liver of laying hens under high-temperature conditions. Experimental groups contained two controls groups (high temperature and thermo-neutral control (HC and NC) fed basal diet) and three high-temperature curcumin treatments groups (HT100, HT200 and HT300). Laying hens in HC and HT groups exposed 6 h/day heat stress (32 +/- 1 degrees C). The results of present study showed that heat stress curcumin treatment group had reduced inflammatory responses (IL-6, IL-1 beta, TNF-alpha) as compared to HC and NC group. Pathological lesions and DNA damage of immune tissues were decreased in heat stress curcumin supplementation as compared to HC and NC group. Furthermore, PCNA, TLR4 and its downstream gene expression as well as protein expression (TLR4, NF-kappa B and PCNA) were significantly down regulated in heat stress curcumin supplemented group as compared to HC and NC group. Therefore, it is concluded that heat stressed hens supplemented with dietary curcumin enhance the immunity of laying hens and combat stressful environmental conditions.