文献类型：期刊文献

英文题名：Fabrication and hemostasis evaluation of a carboxymethyl chitosan/sodium alginate/ Resina Draconis composite sponge

作者：Zhang, Dongying[1];Hu, Zhang[2];Hao, Ruijuan[1];Ouyang, Qianqian[3];Wang, Chen[1];Hu, Qin[1];Li, Hang[1];Li, Sidong[2];Zhu, Chunhua[1]

机构：[1]Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Dev & Res Ctr Biol Marine Resources, Zhanjiang 524006, Peoples R China;[2]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[3]Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China

年份：2024

卷号：274

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001262558400001)、、EI(收录号：20242616422970)、Scopus(收录号：2-s2.0-85196807586)、WOS

基金：We acknowledge financial support from Key Projects of Colleges and Universities in Guangdong Province (2022ZDZX2027) , Guangdong Ocean University Undergraduate Innovation Team Project (CXTD2021020) , Guangdong Ocean University (030301022301) , Major Science and Technology Plan of Hainan Province (ZDKJ2021011) , and Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang) (ZJW-2023-10) .

语种：英文

外文关键词：Carboxymethyl chitosan; Sodium alginate; Resina Draconis; Hemostasis

外文摘要：Hemostasis is the first step of emergency medical treatment. It is particularly important to develop rapid-acting and efficacious hemostatic materials. Carboxymethyl chitosan (CMCS), sodium alginate (SA) and Resina Draconis (RD) were composited uniformly by polyelectrolyte blending. Their composite sponges (CMCS/SA/RD) were prepared by freeze-induced phase separation. CMCS/SA/RD sponges were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy, and their blood absorption and hemolysis ratio were analyzed. The hemostatic effect of the composite sponges was evaluated by coagulation in vitro and in vivo. The composite sponges had a porous network structure. The water absorption ratio was >8000 %, and hemolysis ratio was <5 %. CMCS/SA/RD-II and CMCS/SA/RD-III composite sponges shortened the coagulation time in vitro by 11.33 s and 9.66 s, the hepatic hemostasis time by 13.8 % and 23.3 %, and the hemostasis time after mouse-tail amputation by 28.9 % and 23.9 %, respectively. A preliminary study on its coagulation mechanism showed that CMCS/SA/RD had significant effects on erythrocyte adsorption, platelet adhesion, and shortening of the activated partial thromboplastin time.