文献类型：期刊文献

英文题名：Angiotensin I-converting enzyme inhibitory activity of Acetes chinensis peptic hydrolysate and its antihypertensive effect in spontaneously hypertensive rats

作者：Zhang, Chaohua[1];Cao, Wenhong[1];Hong, Pengzhi[1];Ji, Hongwu[1];Qin, Xiaoming[1];He, Jinfeng[2]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524025, Guangdong, Peoples R China;[2]Quartermaster Res Inst Gen Logist, Dept PLA, Beijing 10010, Peoples R China

年份：2009

卷号：44

期号：10

起止页码：2042

外文期刊名：INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000269874500023)、、WOS

基金：This work was supported by funds from the opening funds of the Institute of Marine Drugs, Ocean University of China; Key Laboratory of Marine Drugs, Ministry of Education of the People's Republic of China [No. KLMD(OUC)2004], and Science and Technology Exploration Plan Research Funding of Zhanjiang Municipality [No. 2003 (104)].

语种：英文

外文关键词：Acetes chinensis; angiotensin I-converting enzyme inhibitory activity; antihypertensive effect; enzymatic hydrolysis; peptide absorption; ultrafiltration

外文摘要：P>Peptic hydrolysate with angiotensin I-converting enzyme (ACE) inhibitory activity was prepared from Acetes chinensis. The 3 kDa ultrafiltration filtrates (UF-IV) of the desalted hydrolysate exerted a potent ACE inhibitory activity with IC50 being 0.67 mg mL-1. The fractions with molecular weight located between 611 and 240 Da achieved a total percentage of 63.6% in the UF-IV, with a mean peptide length of about 5.6-2.1. Gastrointestinal digestions were simulated on the hydrolysate and UF-IV and addressed their effect on the ACE inhibitory activity. The ACE inhibitory activity of the UF-IV could survive or be maintained in active form by simulated gastrointestinal digestion. Furthermore, the UF-IV exerted potent antihypertensive effect after oral administrations were given to spontaneously hypertensive rats (SHR) at a dose of 900 mg kg-1 body weight. In conclusion, the UF-IV could serve as useful antihypertensive peptides in the prevention and treatment of hypertension and other associated disorders.