文献类型：期刊文献

英文题名：The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization

作者：Du, Xiaodong[1];Fan, Guangyi[2,7];Jiao, Yu[1];Zhang, He[7];Guo, Ximing[3];Huang, Ronglian[1];Zheng, Zhe[1];Bian, Chao[7];Deng, Yuewen[1];Wang, Qingheng[1];Wang, Zhongduo[1];Liang, Xinming[7];Liang, Haiying[1];Shi, Chengcheng[7];Zhao, Xiaoxia[1];Sun, Fengming;Hao, Ruijuan[1];Bai, Jie[7];Liu, Jialiang[1];Chen, Wenbin[7];Liang, Jinlian[1];Liu, Weiqing;Xu, Zhe[5];Shi, Qiong[7];Xu, Xun[7];Zhang, Guofan[4,6];Liu, Xin[7]

机构：[1]Guangdong Ocean Univ, Fishery Coll, Zhanjiang 524025, Peoples R China;[2]BGI Qingdao, Qingdao 266555, Peoples R China;[3]Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ 08349 USA;[4]Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China;[5]Atlantic Cape Community Coll, Mays Landing, NJ 08330 USA;[6]Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China;[7]BGI Shenzhen, Shenzhen 518083, Peoples R China

年份：2017

卷号：6

期号：8

外文期刊名：GIGASCIENCE

收录：SCI-EXPANDED(收录号：WOS:000407470900001)、、WOS

基金：This research is partly supported the Guangdong Ocean University Nature Science Foundation (University program: Genome studies of pearl oyster), the National Nature Science Foundation of China (31272635, 31372526, 31672626), Modern Agro-industry Technology Research System (CARS-48), USDA/NJAES Project 1004475/NJ32920 and "Taishan Oversea Scholar" program.

语种：英文

外文关键词：genome; biomineralization; nacre; VWA-containing protein; Pinctada fucata martensii

外文摘要：Background: Nacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process of matrix-assisted biomineralization. Despite recent advances, many aspects of the biomineralization process and its evolutionary origin remain unknown. The pearl oyster Pinctada fucata martensii is a well-known master of biomineralization, but the molecular mechanisms that underlie its production of shells and pearls are not fully understood. Results: We sequenced the highly polymorphic genome of the pearl oyster and conducted multi-omic and biochemical studies to probe nacre formation. We identified a large set of novel proteins participating in matrix-framework formation, many in expanded families, including components similar to that found in vertebrate bones such as collagen-related VWA-containing proteins (VWAP), chondroitin sulfotransferases and regulatory elements. Conclusions: Considering that there are only collagen-based matrices in vertebrate bones and chitin-based matrices in most invertebrate skeletons, the presence of both chitin and elements of collagen-based matrices in nacre suggests that elements of chitin-and collagen-based matrices have deep roots and might be part of an ancient biomineralizing matrix. Our results expand the current shell matrix-framework model and provide new insights into the evolution of diverse biomineralization systems.