文献类型：期刊文献

英文题名：Ultrasmall copper-based clusterzymes ameliorate Achilles tendinopathy by inhibiting acute oxidative stress

作者：Chen, Xuzhuo[1,2,3,4,5,6];Du, Yi[7];Huang, Yazi[9];Zhou, Xianhao[10];Xie, Xinru[1,2,3,4,5,6];Li, Chang[8];Zhao, Chen[10];Dai, Fengrong[8];Yu, Xijiao[7];Zhang, Shanyong[1,2,3,4,5,6]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Oral Surg, Shanghai 200011, Peoples R China;[2]ShanghaiJiao Tong Univ, Coll Stomatol, Shanghai 200011, Peoples R China;[3]Natl Ctr Stomatol, Shanghai 200011, Peoples R China;[4]Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China;[5]Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China;[6]Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China;[7]Jinan Stomatol Hosp, Dept Endodont, Jinan Key Lab Oral Tissue Regenerat, Cent Lab,Shandong Prov Hlth Commiss Key Lab Oral D, Jinan 250001, Peoples R China;[8]Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Peoples R China;[9]Guangdong Ocean Univ, Coll Chem & Environm, Dept Chem, Zhanjiang 524088, Peoples R China;[10]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthoped, Shanghai Key Lab Orthoped Implant,Sch Med, Shanghai 200011, Peoples R China

年份：2024

外文期刊名：NANO RESEARCH

收录：SCI-EXPANDED(收录号：WOS:001145981000003)、、Scopus(收录号：2-s2.0-85182676455)、WOS

基金：This work was supported by the Open Project of Shandong Provincial Health Commission Key Laboratory of Oral Diseases and Tissue Regeneration (No. 2023KF001), China Postdoctoral Science Foundation (No. 2023M732281), the National Natural Science Foundation of China (Nos. 82301108, and 82071135), and the Natural Science Foundation of Shandong Province (No. ZR2021MH230).

语种：英文

外文关键词：nanoclusters; clusterzymes; oxidative stress; tendinopathy; reactive oxygen species (ROS)

外文摘要：Tendinopathy is a prevalent musculoskeletal disorder, accounting for over 30% of musculoskeletal lesions. However, current therapeutic strategies for tendinopathy are limited and often yield unsatisfactory clinical outcomes. Therefore, there is a critical need to explore novel therapeutic approaches with minimal side effects for tendinopathy and its early lesions. In this study, we successfully designed and synthesized a copper(I)-based nanocluster, named Cu11, which possesses remarkable enzyme-like and ROS-scavenging activities. This unique combination of properties qualifies Cu11 as an attractive anti-inflammatory and anti-ROS agent. The Cu11 clusterzymes specifically target mitochondria, effectively scavenging excessive reactive oxygen species (ROS) and reducing oxidative stress. Furthermore, Cu11 clusterzymes inhibit the activation of key signaling pathways involved in inflammation, namely tumor necrosis factor (TNF), mitogen-activated protein kinase (MAPK), and nuclear factor (NF)-kappa B, leading to a decrease in the release of proinflammatory cytokines. Excitingly, our in vivo experiments using a collagenase-induced acute Achilles tendinopathy model demonstrated that Cu11 clusterzymes effectively alleviate inflammation and oxidative stress, without causing systemic toxicity. This study highlights the potential of copper-based clusterzymes as therapeutic agents for the treatment of Achilles tendinopathy and other inflammatory diseases. The unique enzyme-like and ROS-scavenging activities of Cu11 make it a promising candidate for further development and clinical translation.