文献类型：期刊文献

中文题名：双齿围沙蚕超滤组分对秀丽隐杆线虫的延缓衰老作用及其机制

英文题名：Anti-aging Effect of Ultrafiltration Components of Perinereis aibuhitensis on Caenorhabditis elegans and Its Mechanism

作者：Su, Ju[1]; Zhu, Guoping[1]; Cao, Wenhong[1]; Chen, Zhongqin[1]; Tan, Mingtang[1]; Zheng, Huina[1]; Gao, Jialong[1]; Lin, Haisheng[1]

机构：[1] College of Food Science and Technology, Guangdong Ocean University, National Research and Development Branch Center for Shellfish Processing [Zhanjiang], Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang, 524088, China

年份：2026

卷号：47

期号：17

起止页码：527

外文期刊名：Science and Technology of Food Industry

收录：EI(收录号：20263621412363)

语种：中文

外文关键词：Antioxidants - Gene expression - Plants (botany)

外文摘要：This study investigated the anti-aging effects of three ultrafiltration fractions (EPU-1 (8 kDa)) derived from the enzymatic hydrolysate of Perinereis aibuhitensis on Caenorhabditis elegans. The basic nutritional composition of each fraction was determined, and their in vitro antioxidant activity was evaluated based on hydroxyl radical and superoxide anion scavenging capacities. Using nematode as the model organism, the effects of these fractions were assessed with respect to stress resistance, lifespan, locomotion, fecundity, and lipofuscin accumulation. Furthermore, the expression levels of gene expression associated with the insulin/IGF-1 signaling (IIS) pathway were measured to explore the underlying anti-aging mechanisms. The results indicated that EPU-1 and EPU-2 were rich in peptides, with contents of 44.20% and 40.41%, respectively, whereas EPU-3 contained only 4.60% peptides. All three fractions exhibited strong in vitro and in vivo antioxidant activities and significantly delayed aging in nematode. Among them, EPU-1 demonstrated the most potent antioxidant and anti-aging effects. Its hydroxyl radical and superoxide anion scavenging capacities were significantly higher than those of EPU-2 and EPU-3 (P ? The Author(s) 2026.