文献类型：期刊文献

英文题名：Research progress and prospects for the use of aptamers in aquaculture biosecurity

作者：Yu, Qing[1];Liu, Mingzhu[1];Wei, Shina[2];Qin, Xianling[3];Qin, Qiwei[2];Li, Pengfei[1,4]

机构：[1]Guangxi Acad Sci, Beibu Gulf Marine Ind Res Inst, Adv Technol R&D Ctr, Guangxi Beibu Gulf Marine Res Ctr,Guangxi Key Lab, Nanning, Peoples R China;[2]South China Agr Univ, Coll Marine Sci, Guangdong Lab Lingnan Modem Agr, Guangzhou, Peoples R China;[3]Guangxi Acad Sci, Guangxi Beibu Gulf Marine Res Ctr, Guangxi Key Lab Marine Environm Sci, Nanning, Peoples R China;[4]Guangdong Ocean Univ, Coll Fishery, Guangdong Key Lab Control Dis Aquat Econ Anim, Guangdong Prov Key Lab Pathogen Biol & Epidemiol, Zhanjiang, Peoples R China

年份：2021

卷号：534

外文期刊名：AQUACULTURE

收录：SCI-EXPANDED(收录号：WOS:000614763900002)、、Scopus(收录号：2-s2.0-85097755748)、WOS

基金：This work was supported by grants from the National Natural Science Foundation of China (41706145; 41966004), Key Research and Development Programs of Guangxi (AB18221111), Natural Science Foundation of Guangxi (AD19245022; 2019GXNSFAA245054; 2018GXNSFBA281011), Basic Research Fund of Guangxi Academy of Sciences (2018YJJ903; 2019YJJ1005; 2018YJJ902). We would like to thank the Light of the Western China Visiting Scholar Program and Outstanding Chinese and Foreign Youth Exchange Program of China Association of Science and Technology.

语种：英文

外文关键词：Aquaculture biosecurity; Pathogens; Aptamer; Rapid detection and therapeutic assays; Pathogenesis

外文摘要：The rapidly expanding scale of aquaculture has resulted in frequent pathogen outbreaks. Herein we review and discuss the application of aptamers in aquaculture biosecurity, including their use in the development of rapid diagnostic assays and effective therapeutic agents against aquaculture pathogens. First, we describe examples of aptamers against aquatic pathogens, including bacteria, viruses, and algal toxins. Aptamers are "artificial antibodies" that can recognize targets with high specificity and affinity. Second, we explore the current state of aptamer-based detection technology. Based on their high specificity, aptamers can be used to develop sensitive biosensors to detect aquatic pathogens through signal amplification. Third, we give examples of some of the existing therapies that are being used against aquatic pathogens. Some aptamers have antiviral abilities without affecting cell viability, which allows their use in the development of novel antiviral therapies. Furthermore, due to their small size and specific recognition of targets, aptamers are powerful molecular tools for cell biomarker identification and pathogenesis research. Fourth, we describe how aptamers are being used in pathogenesis research, and finally we discuss future perspectives of aptamer use in the management of aquatic animal health.