文献类型：会议论文

英文题名：Optimization of preparation process and characterization of carboxymethyl chitosan/sodium alginate hemostatic sponge

作者：Hu, Z.[1];Ouyang, Q. Q.[1];Cheng, Y.[1];Hong, P. Z.[2];Liao, M. N.[1];Chen, F. J.[3];Li, S. D.[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[3]Guangdong Ocean Univ, Fac Ocean & Meteorol, Zhanjiang 524088, Peoples R China

会议论文集：Global Conference on Polymer and Composite Materials (PCM)

会议日期：MAY 23-25, 2017

会议地点：Guangzhou, PEOPLES R CHINA

语种：英文

外文关键词：Porosity - Vacuum applications - Chitosan - Sodium - Sodium alginate - Water absorption

外文摘要：Composite hemostatic sponge was prepared by vacuum freeze-drying using carboxymethyl chitosan and sodium alginate as the main materials and CaCl2 as a crosslinking agent. On the basis of single factor experiments, an orthogonal experiment was carried out to optimize the preparation process of hemostatic sponge. The appearance, water absorption, porosity ratio, and in vitro hemostasis of the sponge were evaluated. The optimum conditions to prepare hemostatic sponge were obtained as follows: mass ratio of sodium alginate to carboxymethyl chitosan 4: 1, mass fraction of CaCl2 2%, and crosslinking temperature 30 degrees C. The hemostatic sponge prepared under such conditions was off-white and porous. Its water absorption and porosity ratio were 3050% and 67.23%, respectively. Meanwhile, the hemostatic sponges had significant in vitro procoagulant activity. Therefore, the hemostatic sponge is expected to be developed as a novel medical material.