文献类型：期刊文献

英文题名：Dietary lipid levels modulate enrofloxacin-induced antibiotic resistance and metabolic dysfunction in Pacific white shrimp (Litopenaeus vannamei): assessing the dietary risk and metabolic impact in edible tissues

作者：Song, Jiahao[1];Liu, Yucheng[1];Pan, Yifei[1];Qu, Kangyuan[1];Huang, Bin[1];Chen, Xianjie[1];Ma, Yuxuan[1];Li, Youxi[1];Chen, Jiajie[1];Chi, Shuyan[1];Tan, Beiping[1];Xie, Shiwei[1]

机构：[1]Guangdong Ocean Univ, Coll Fisheries, Lab Aquat Anim Nutr & Feed, Zhanjiang 524088, Peoples R China

年份：2026

卷号：513

外文期刊名：FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:001732399500001)、、EI(收录号：20261520463448)、WOS

基金：This study was supported by the fund of the National Key Research and Development Program of China (2023YFD2402000) , the National Natural Science Foundation of China and the National Natural Science Foundation of China Youth Fund (32373141) , and Guangdong Province Basic and Applied Basic Research Fund (2023A1515030007) .

语种：英文

外文关键词：Enrofloxacin; Antibiotic resistance; Food safety; Health risk; Intestinal microbiota

外文摘要：The persistent use of enrofloxacin (ENR) in aquaculture poses significant risks to food safety. This study examined the interaction between dietary lipid levels (4.99%, 7.94%, and 10.88%) and ENR (0.04%) in Litopenaeus vannamei. A high-lipid diet significantly increased ENR residues, upregulated antibiotic resistance genes, and disrupted the intestinal microbiota by promoting pathogenic Vibrio. Transcriptomic analysis showed that under ENR exposure, a high-fat diet suppressed V-type proton ATPase and key structural genes in shrimp, thereby weakening the physical defenses of the hepatopancreas and resulting in impaired immunity and increased susceptibility to Vibrio. In addition, risk assessment indicated increased health concerns associated with hepatopancreas consumption. Overall, these findings demonstrate that excessive dietary lipids exacerbate ENR persistence, induce microbial and immune dysfunction, and intensify food safety risks.