文献类型：期刊文献

中文题名：Cordycepssinensis CAMT63341液态发酵多糖对小鼠若干行为学指标及免疫器官指数的影响

英文题名：Effect of Polysaccharides from Liquid Culture of Cordyceps sinensis CAMT 63341 on Behavior and Immunity Organ Indexes of Mice

作者：蔡创威[1];黄晓月[1];聂芳红[1];徐德峰[1,2,3];郝江伟[1]

机构：[1]广东海洋大学食品科技学院,广东省水产品加工与安全重点实验室,广东省海洋食品工程技术研究中心,水产品深加工广东普通高等学校重点实验室,广东湛江524088;[2]华南理工大学食品科学与工程学院,广东广州510640;[3]无限极(中国)有限公司技术中心,广东广州510665

年份：2018

卷号：39

期号：1

起止页码：232

中文期刊名：食品科学

外文期刊名：Food Science

收录：CSTPCD、、CSCD_E2017_2018、EI(收录号：20181304959129)、北大核心2017、Scopus、北大核心、CSCD

基金：中国博士后科学基金项目(2014M552203);中央高校基本科研业务费专项资金项目(20152M062);广东省科技厅项目(2013B021100016)

语种：中文

中文关键词：Cordycepssinensis;CAMT63341;液态发酵;多糖;情绪;认知;免疫

外文关键词：Cordyceps sinensis CAMT 63341; liquid-state fermentation; polysaccharides; emotion; recognition; immunity

中文摘要：为评价虫草菌(Cordyceps sinensis)CAMT 63341液态发酵多糖对小鼠生长、情绪、认知和免疫的影响,将60只健康雄性昆明小鼠随机分成空白对照、灵芝多糖对照和Cordyceps sinensis CAMT 63341发酵多糖高、中、低剂量饲喂组连续喂养30 d,然后行高架十字迷宫、穿梭箱、迟发型超敏反应实验,并记录小鼠体质量和免疫器官指数。结果表明:与空白对照组相比,Cordyceps sinensis CAMT 63341发酵多糖可剂量依赖性促进小鼠生长,增加高架迷宫开放臂次数和延长停留时间,增强穿梭箱实验中主动回避能力和缩短被动回避潜伏期,提升胸腺和脾脏器官指数,其中,高剂量组达到显著(P<0.05)或极显著水平(P<0.01),接近灵芝多糖对照组,提示Cordyceps sinensis CAMT 63341液态发酵多糖具有一定的促进生长、改善情绪、增强认知和提升免疫功能。

外文摘要：This investigation was undertaken to evaluate the effect of polysaccharides from the liquid culture of Cordyceps sinensis CAMT 63341 on body weight, emotion, cognition and immune function in mice. Totally 60 healthy male mice were randomly divided into blank control, positive control and experimental groups. Ganoderma lucidum polysaccharides were taken as positive control, and the animals in the experimental groups were given Cordyceps sinensis CAMT 63341 polysaccharides at high, middle, and low doses, respectively. After continuous feeding for 30 days, elevated plus maze test, shuttle box test, and delayed type hypersensitivity test were conducted and the body weight and thymus and spleen organ weight to body weight ratios were recorded. Compared with the blank control group, the mice fed with Cordyceps sinensis CAMT 63341 polysaccharides exhibited dose-dependently accelerated body weight gain, increased number of open arm entries and extended time spent on the open arm of the maze, improved active avoidance response and shortened latent period of passive avoidance in shuttle box test, and increased thymus and spleen organ weight to body weight ratios, with statistically signi？cant differences being observed in the high-dose group （P 〈 0.05 or 0.01）, which was similarly effective to Ganoderma lucidum polysaccharides. Therefore, polysaccharides from the liquid culture of Cordyceps sinensis CAMT 63341 can promote body weight gain, improve emotion, and enhance cognition and immune function in mice.