文献类型：期刊文献

英文题名：Effect of different molecular weight of chitosans on performance and lipid metabolism in chicken

作者：Li, Q. P.[1];Gooneratne, S. R.[2];Wang, R. L.[1];Zhang, R.[3];An, L. L.[1];Chen, J. J.[1];Pan, W.[1]

机构：[1]Guangdong Ocean Univ, Dept Anim Sci, Zhanjiang City 524088, Guangdong, Peoples R China;[2]Lincoln Univ, Ctr Food Res & Innovat, Dept Wine Food & Mol Biosci, Fac Agr & Life Sci, Canterbury, New Zealand;[3]Guangdong Ocean Univ, Expt Teaching Dept, Ctr Modern Biochem, Zhanjiang 524088, Guangdong, Peoples R China

年份：2016

卷号：211

起止页码：174

外文期刊名：ANIMAL FEED SCIENCE AND TECHNOLOGY

收录：SCI-EXPANDED(收录号：WOS:000369562200018)、、Scopus(收录号：2-s2.0-84955192834)、WOS

基金：This research was supported by Guangdong Natural Science Foundation of China (S2012010010114).

语种：英文

外文关键词：Chitosan; Molecular weight; Fat metabolism; Broiler

外文摘要：The effect of different molecular weight (MW) chitosans on lipid metabolism, body fat deposition, growth performance and mechanism of action of chitosans in broilers was investigated. A total of 192, 50-day-old local feather-frizzled female broilers with similar initial body weight (583 +/- 4 g) were randomly divided into four groups with eight replicates of six broilers each and fed a corn-soybean meal based diet containing 0 (control), 2 (LMWC), 5 (MMWC) and 50 (HMWC) kDa MW chitosan for 42 days. Treatments did not affect the growth performance. The LMWC had no influence on fecal lipids, apparent fat metabolisability and serum concentrations of total cholesterol (TC) and triglyceride (TG), and decreased (P < 0.05) the fat accumulation in both liver and muscle and abdominal fat yield. The MMWC and HMWC feeding increased fecal lipid excretion, decreased the fat accumulation in both liver and muscle and abdominal fat yield and also the serum concentrations of TC and TG (P < 0.05). Both LMWC and MMWC reduced liver fatty acid synthase (FAS) activity (P < 0.01), and increased liver lipoprotein lipase (LPL) and hepatic lipase activities (P < 0.05). However, the HMWC feeding did not affect activities of tissue lipases except for a reduction in liver FAS activity. All three forms of chitosans improved the antioxidant status as seen by increased serum superoxide dismutase activity and decreased malondialdehyde content (P < 0.05). The liver FAS mRNA did not differ among the treatment groups. There was a trend (P = 0.077) for liver LPL mRNA to decrease as the chitosan MW increased. In conclusion, the three chitosans regardless of MW inhibited body fat deposition in broilers. The lipid-lowering effect of 50 kDa chitosan is probably mediated by reduced dietary fat absorption. The 2 kDa chitosan was useful in inducing fat catabolism, and the 5 kDa chitosan appeared to act via both these mechanisms. (C) 2015 Published by Elsevier B.V.