文献类型：期刊文献

英文题名：Weighted Gene Co-Expression Network Analysis of red body color formation of crimson snapper, Lutjanus erythropterus

作者：Xu, Zhenmin[1];Liang, Qiulu[1];Chen, Zizhao[1];Dong, Zhongdian[1];Guo, Yusong[1];Wang, Zhongduo[1,2]

机构：[1]Guangdong Ocean Univ, Key Lab Aquaculture South China Sea Aquat Econ Ani, Fisheries Coll, Guangdong Higher Educ Inst, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Fisheries Coll, Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Zhanjiang 524088, Peoples R China

年份：2023

卷号：31

外文期刊名：AQUACULTURE REPORTS

收录：SCI-EXPANDED(收录号：WOS:001040968000001)、、Scopus(收录号：2-s2.0-85164337085)、WOS

基金：This research was financially sponsored by the National Nature Science Foundation of China (31972794) and the Project of Enhancing School with Innovation of Guangdong Ocean University (230419055) , and the project of the innovation team for the Innovation and Utilization of Economic Animal Germplasm in the South China Sea (2021KCXTD026) .

语种：英文

外文关键词：Lutjanus erythropterus; Early development; Coloration; WGCNA; Transcriptomics

外文摘要：Crimson snapper (Lutjanus erythropterus) is a highly valued economic fish species, with its red body color being a crucial economic characteristic. A systematic study of skin pigmentation could offer insights into the mechanism of red coloration. In this study, we conducted the first network analysis of snapper transcriptomes during key developmental stages of pigmentation, identifying a cascade of cellular development and responsive gene modules and key genes, including eight developmental-specific modules. Among the four candidate hub genes (TNNT2, ROBO2, APBA2, and APOD), APOD was involved in pigmentation development. The network further revealed some key genes, such as TYRP1a, TYRP1b, PMEL, BCO1, BCO2, CYP2J2, CYP2J6, CYP3A4, PNPLA2, FABP6, ENPP7, and FFAR3, associated with melanin synthesis, carotenoids, and lipid metabolism. Our findings showed that pteridine and carotenoids were involved in yellow coloration after initial feeding, while yellow pigmentation-related genes (e.g., GCH1, PTS, SPR, CBR1, SCARB1, CD36, ABCA1, NpC1L1, etc.) had the same expression pattern at three days post-hatching (3 dph). At the red coloration emergence stage (45 dph), we observed an RNA level signal indicating the conversion of coloring substances from pteridine to carotenoids. These results substantially enhance understanding of the molecular mechanisms underlying pigmentation and skin color variation in L. erythropterus, providing a theoretical basis for improving of body coloration in economically cultured fish and genetic breeding of ornamental fish.