文献类型：期刊文献

英文题名：Effects of T-2 toxin on growth, immune function and hepatopancreas microstructure of shrimp (Litopenaeus vannamei)

作者：Qiu, Mei[1];Wang, Yaling[1];Wang, Xiaobo[1];Sun, Lijun[1];Ye, Riying[1];Xu, Defeng[1];Dai, Zhe[1];Liu, Ying[1];Bi, Siyuan[2];Yao, Yanpo[3];Gooneratne, Ravi[4]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Zhanjiang 524088, Peoples R China;[2]Shenzhen Bioeasy Biotechnol Co Ltd, Shenzhen 518102, Peoples R China;[3]Chinese Acad Agr Sci, Oilcrops Res Inst, Wuhan 430062, Peoples R China;[4]Lincoln Univ, Fac Agr & Life Sci, Dept Wine Food & Mol Biosci, Ctr Food Res & Innovat, POB 85084, Lincoln 7647, New Zealand

年份：2016

卷号：462

起止页码：35

外文期刊名：AQUACULTURE

收录：SCI-EXPANDED(收录号：WOS:000377295900006)、、Scopus(收录号：2-s2.0-84966705171)、WOS

基金：This study was supported by grants from the National Natural Science Foundation of China (NSFC) (No. 31171634 and No. 31371777), the Science and Technology Planning Project of Guangdong Province (No. 2014B020205006), the Guangdong Oceanic & Fishery Administration Project (Guangdong Fiscal Government on Agriculture [2015] No. 115), the Enhancing Innovation Project of Guangdong Ocean University (No. 2013050205 and No. 2014050203 and GDOU2013050312), and the Shenzhen Technology Research & Development Foundation Project (GCZX201405091631511273).

语种：英文

外文关键词：T-2 toxin; Growth; Immuno-physiological parameters; Histopathology

外文摘要：T-2 toxin (T-2) is a trichothecene-A-type mycotoxin produced by the fungus Fusarium spp., which can contaminate animal feed. It is toxic to many living cells especially the hepatocytes and bone marrow cells. The effects of dietary T-2 on growth, biochemical and immunity parameters, and histopathological changes in the hepatopancreas of white shrimp (Litopenaeus vannamei) were studied. Shrimp with an initial body weight of 3.5 +/- 0.5 g were fed five diets (n = 50/group) containing 0, 0.5, 1.2, 2.4, or 4.8 mg kg(-1) T-2. Dietary exposure to T-2 significantly decreased shrimp growth rate and specific growth rate (P < 0.5), but not the fat content, compared with the control group. Exposure to T-2 damaged the hepatopancreas microstructure in a dose-dependent manner and this may have contributed to a lower hemolymph albumin concentration and lower phenoloxidase activity. Total hemocyte counts and activity of hemolymph glutamic-pyruvic transaminase > glutamic-oxaloacetic transaminase and alkaline phosphatase enzymes increased initially in a dose-dependent manner but declined thereafter. This study showed that T-2 is a multi-organ toxin with effects on the hemolymph, immune system, and hepatopancreas of shrimp. Collectively, these effects may have contributed to the inhibition of growth and decreased survival rate leading to a lower yield and quality of shrimp meat with resultant economic loss. (C) 2016 Elsevier B.V. All rights reserved.