文献类型：期刊文献

英文题名：Grafting of 18β-Glycyrrhetinic Acid and Sialic Acid onto Chitosan to Produce a New Amphipathic Chitosan Derivative: Synthesis, Characterization, and Cytotoxicity

作者：Quan, Wei-Yan[1];Kong, Song-Zhi[1];Li, Si-Dong[1,2];Liu, Hua-Zhong[1];Ouyang, Qian-Qian[2];Huang, Yong-Mei[2];Luo, Hui[2,3]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Dept Appl Chem, Zhanjiang 524088, Peoples R China;[2]Guangdong Med Univ, Marine Biomed Res Inst, Zhanjiang 524023, Peoples R China;[3]Marine Biomed Res Inst Guangdong Zhanjiang, Zhanjiang 524023, Peoples R China

年份：2021

卷号：26

期号：2

外文期刊名：MOLECULES

收录：SCI-EXPANDED(收录号：WOS:000611471700001)、、Scopus(收录号：2-s2.0-85100326606)、WOS

基金：This work was supported by the National Natural Science Foundation of China (81803684), Natural Science Foundation of Guangdong Province (2018A030313416), Science and Technology Program of Guangdong Province (2019B090905011), the Key Laboratory of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim (2012E02), and the Public Service Platform of South China Sea for R&D Marine Biomedicine Resources (2017C8Q)

语种：英文

外文关键词：chitosan; chitosan derivatives; 18β -glycyrrhetinic acid; sialic acid; cytotoxicity

外文摘要：Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18 beta-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18 beta-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 beta-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.