文献类型：期刊文献

英文题名：Wnt/β-Catenin Signaling Contributes to Vincristine-Induced Neuropathic Pain

作者：Hu, Chuanyin[1];Zhao, Yun-Tao[2];Cui, Yan-Bing[3];Zhang, Hua-Hua[1];Huang, Geng-Li[2];Liu, You[2];Liu, Yan-Fen[2,3]

机构：[1]Guangdong Med Univ, Dept Biol, Zhanjiang, Guangdong, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci, Dept Bioengn, 1 Hai Da Rd, Zhanjiang 524088, Guangdong, Peoples R China;[3]Guangdong Ocean Univ, Coll Agr, 1 Hai Da Rd, Zhanjiang 524088, Guangdong, Peoples R China

年份：2020

卷号：69

期号：4

起止页码：701

外文期刊名：PHYSIOLOGICAL RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000563323000013)、、Scopus(收录号：2-s2.0-85090251998)、WOS

基金：The present study was supported by grants from the Science and Technology Projects of Guangdong Province (2014A020212507), the Guangdong Medical University Student Innovation Experiment Program (201510571041), the Medical Scientific Research Foundation of Guangdong Province (A2017084), the Scientific Research Fund Project of Guangdong Medical University (Z2016003), the National Science Foundation of Guangdong Province (2017A030307001) and the Project of Enhancing School with Innovation of Guangdong Ocean University (GDOU2013050243).

语种：英文

外文关键词：Wnt/beta-catenin signaling; Chemotherapy-induced neuropathic pain; Vincristine; Inflammation; MAPK/ERK signaling

外文摘要：Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in cancer chemotherapy. However, the mechanisms underlying CNP remain elusive. In the present study, CNP was induced by repeated intraperitoneal injection of vincristine (VCR) into male C57BL/6J mice. VCR administration caused significant activation of Wnt/beta-catenin signaling, which led to the activation of astrocytes, microglia, the release of inflammatory cytokines tumor necrosis factor (TNF)-alpha, monocyte chemoattractant protein-1 (MCP-1) and the activation of subsequent mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) signaling pathway in CNP mice. Blocking Wnt/beta-catenin signaling by intrathecal administration of the inhibitors of Wnt response (IWR) effectively attenuated VCR-induced neuropathic pain. Furthermore, IWR inhibited the activation of astrocytes, microglia, TNF-alpha, MCP-1 and MAPK/ERK signaling in the spinal cord, which was triggered by VCR-induced Wnt/beta-catenin signaling upregulation. These results suggest that Wnt/beta-catenin signaling plays a critical role in VCR-induced neuropathic pain and provides evidence for potential interfering with Wnt/beta-catenin signaling to ameliorate VCR-induced neuropathic pain.