文献类型：期刊文献

英文题名：Genome-wide association study analysis to resolve the key regulatory mechanism of biomineralization in Pinctada fucata martensii

作者：Zheng, Zhe[1];Hao, Ruijuan[2];Yang, Chuangye[1];Jiao, Yu[1];Wang, Qingheng[1];Huang, Ronglian[1];Liao, Yongshan[1];Jian, Jianbo[3];Ming, Yao[3];Yin, Lixin[3];He, Weiming[3];Wang, Ziman[1];Li, Chuyi[1];He, Qi[1];Chen, Kun[1];Deng, Yuewen[1,2,4,5,6];Du, Xiaodong[1,6]

机构：[1]Guangdong Ocean Univ, Fisheries Coll, Zhanjiang, Peoples R China;[2]Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Dev & Res Ctr Biol Marine Resources, Zhanjiang, Peoples R China;[3]BGI Genom, BGI Shenzhen, Shenzhen, Peoples R China;[4]Pearl Breeding & Proc Engn Technol Res Ctr Guangdo, Zhanjiang, Peoples R China;[5]Guangdong Prov Engn Lab Mariculture Organism Breed, Zhanjiang, Peoples R China;[6]Guangdong Ocean Univ, Fisheries Coll, Zhanjiang 524008, Peoples R China

年份：2023

卷号：23

期号：3

起止页码：680

外文期刊名：MOLECULAR ECOLOGY RESOURCES

收录：SCI-EXPANDED(收录号：WOS:000897961300001)、、Scopus(收录号：2-s2.0-85144104083)、WOS

基金：China Agriculture Research System of MOF and MARA; Department of Science and Technology of Guangdong Province, Grant/Award Number: 2021B0202020003; Guangdong Basic and Applied Basic Research Foundation, Grant/Award Number: 2019A1515011096, 2019A1515111026, 2020A1515010691 and 2021A1515011199; Guangdong Provincial Special Fund For Modern Agriculture Industry Technology Innovation Teams, Department of Agriculture and Rural Affairs of Guangdong Province, Grant/Award Number: 2020KJ146; Innovation Team Project from the Department of Education of Guangdong Province, Grant/Award Number: 2021KCXTD026; National Natural Science Foundation of China, Grant/Award Number: 32002369 and 32102817

语种：英文

外文关键词：biomineralization-controlled trait; genome; genome-wide association study; growth; Pinctada fucata martensii; selective sweep; SNP

外文摘要：Biomineralization-controlled exo-/endoskeleton growth contributes to body growth and body size diversity. Molluscan shells undergo ectopic biomineralization to form the exoskeleton and biocalcified "pearl" involved in invading defence. Notably, exo-/endoskeletons have a common ancestral origin, but their regulation and body growth are largely unknown. This study employed the pearl oyster, Pinctada fucata marntensii, a widely used experimental model for biomineralization in invertebrates, to perform whole-genome resequencing of 878 individuals from wild and breeding populations. This study characterized the genetic architecture of biomineralization-controlled growth and ectopic biomineralization. The insulin-like growth factor (IGF) endocrine signal interacted with ancient single-copy transcription factors to form the regulatory network. Moreover, the "cross-phylum" regulation of key long noncoding RNA (lncRNA) in bivalves and mammals indicated the conserved genetic and epigenetic regulation in exo-/endoskeleton growth. Thyroid hormone signal and apoptosis regulation in pearl oysters affected ectopic biomineralization in pearl oyster. These findings provide insights into the mechanism underlying the evolution and regulation of biomineralization in exo-/endoskeleton animals and ectopic biomineralization.