文献类型：期刊文献

英文题名：Effect of Different Levels of Copper and Molybdenum Supplements on Serum Lipid Profiles and Antioxidant Status in Cashmere Goats

作者：Zhang, Wei[2];Zhang, Yu[2];Zhang, Shi W.[3];Song, Xian Z.[3];Jia, Zhi H.[2];Wang, Run L.[1,2]

机构：[1]Guangdong Ocean Univ, Dept Anim Sci, Zhanjiang 524088, Peoples R China;[2]China Agr Univ, State Key Lab Anim Nutr, Coll Anim Sci & Technol, Beijing 100193, Peoples R China;[3]Liaoning Cashmere Goat Breeding Ctr, Liaoning 111001, Peoples R China

年份：2012

卷号：148

期号：3

起止页码：309

外文期刊名：BIOLOGICAL TRACE ELEMENT RESEARCH

收录：SCI-EXPANDED(收录号：WOS:000306543300005)、、Scopus(收录号：2-s2.0-84864645939)、WOS

基金：The research was supported by the Key Program of the National Natural Science Foundation of China (project no. 30901032; Beijing, People's Republic of China). This was also supported in part by a grant from the National Key Technologies R & D Program (project no. 2009BADA5B04; Beijing, People's Republic of China).

语种：英文

外文关键词：Copper; Molybdenum; Serum lipid profiles; Antioxidant status; Cashmere goats

外文摘要：An experiment was conducted to investigate on the effects of different levels of copper (Cu: 0, 19, and 38 mg/kg) and molybdenum (Mo: 0 and 5 mg/kg) supplements and the interaction of these two factors on serum lipid profiles and antioxidant status in cashmere goats during the cashmere fiber growing period. Thirty-six Liaoning cashmere goats (approximately 1.5 years of age; 27.53 +/- 1.38 kg of body weight) were assigned to one of six treatments in a completely randomized design involving a 2 x 3 factorial arrangement. Goats were housed in individual pens and fed with Chinese wild rye- and alfalfa hay-based diet containing 4.72 mg Cu/kg, 0.16 mg Mo/kg, and 0.21 % S for 84 days. Blood samples were collected on day 84. The triglyceride concentration did not differ among treatments (P > 0.05). Supplemental Cu, regardless of Mo level, decreased (P < 0.05) the concentrations of serum total cholesterol and low density lipoprotein cholesterol, and increased (P < 0.05) the concentration of serum high density lipoprotein cholesterol, but there were no differences (P > 0.05) in these values between Cu-supplemented groups. Supplemental Cu increased (P < 0.05) the activities of serum ceruloplasmin (Cp), Cu-zinc superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), and decreased (P < 0.05) the malondialdehyde content. The serum GSH-Px activity was also increased (P < 0.05) by Mo supplementation. There was a tendency of the interaction effects of Cu and Mo on the activities of Cp (P = 0.094), SOD (P = 0.057), and GSH-Px (P = 0.062), and goats fed with 19 mg Cu/kg in the absence of Mo tended to show the highest serum SOD activity, while goats fed with 38 mg Cu/kg with 5 mg Mo/kg tended to show the highest values of serum Cp and GSH-Px. Addition of Cu, Mo, or their interaction had no influence (P > 0.05) on the activities of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and lactate dehydrogenase, and the concentrations of serum glucose and total protein. In conclusion, addition of 19 mg Cu/kg in the absence of Mo (the total dietary Cu level of 23.72 mg/kg) was recommended for altering the fat metabolism and obtaining the optimal antioxidant activity of cashmere goats, while 38 mg Cu/kg should be supplemented when 5 mg Mo/kg was added in the basal diet (the total dietary level of 42.72 mg Cu/kg, 5.16 mg Mo/kg, and 0.21 % S) during the cashmere growing period.