文献类型：期刊文献

英文题名：Marine algal polysaccharides as future potential constituents against non-alcoholic steatohepatitis

作者：Lu, Si-Yuan[1,3];Tan, Karsoon[2];Zhong, Saiyi[1];Cheong, Kit -Leong[1,3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang, Peoples R China;[2]Beibu Gulf Univ, Guangxi Key Lab Beibu Gulf Biodivers Conservat, Qinzhou, Guangxi, Peoples R China;[3]Shantou Univ, Coll Sci, Dept Biol, Guangdong Prov Key Lab Marine Biotechnol, Shantou, Guangdong, Peoples R China

年份：2023

卷号：250

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001148388500001)、、EI(收录号：20233314568096)、Scopus(收录号：2-s2.0-85167826125)、WOS

基金：This research was financially supported by: Key-Area Research and Development Program of Guangdong Province (2020B1111030004) ; The Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) ; The Program for Scientific Research Start-up Funds of Guangdong Ocean University (060302042302) .

语种：英文

外文关键词：NASH; Functional food; Seaweeds

外文摘要：Non-alcoholic steatohepatitis (NASH) is one of the most chronic and incurable liver diseases triggered mainly by an inappropriate diet and hereditary factors which burden liver metabolic stress, and may result in liver fibrosis or even cancer. While the available drugs show adverse side effects. The non-toxic bioactive molecules derived from natural resources, particularly marine algal polysaccharides (MAPs), present significant potential for treating NASH. In this review, we summarized the protective effects of MAPs on NASH from multiple perspectives, including reducing oxidative stress, regulating lipid metabolism, enhancing immune function, preventing fibrosis, and providing cell protection. Furthermore, the mechanisms of MAPs in treating NASH were comprehensively described. Additionally, we highlight the influences of the special structures of MAPs on their bioactive differences. Through this comprehensive review, we aim to further elucidate the molecular mechanisms of MAPs in NASH and inspire insights for deeper research on the functional food and clinical applications of MAPs.