文献类型：期刊文献

英文题名：Chronic Dietary Exposure to Deltamethrin Impaired Shrimp Growth and Intestinal Health While Not Inducing Deltamethrin Residues

作者：Qu, Kangyuan[1]; Xie, Shiwei[1,2,3,4]; Shi, Menglin[1]; Chen, Liutong[1]; Liu, Yucheng[1]; Li, Xiaoyue[1]; Yao, Xinzhou[1]; Tan, Beiping[1,2,3]

机构：[1] Laboratory of Aquatic Nutrition and Feed, College of Fisheries, Guangdong Ocean University, Zhanjiang, 524088, China; [2] Aquatic Animals Precision Nutrition and High-Efficiency Feed Engineering Research Centre of Guangdong Province, Zhanjiang, 524088, China; [3] Key Laboratory of Aquatic, Livestock and Poultry Feed Science and Technology in South China, Ministry of Agriculture, Zhanjiang, 524088, China; [4] Guangdong Provincial Key Lab of Aquatic Animals Disease Control and Healthy Culture, Zhanjiang, 524088, China

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240146211)

语种：英文

外文关键词：Antioxidants - Detoxification - Enzyme activity - Genes - Tanks (containers) - Toxicity

外文摘要：Deltamethrin (DM) has excellent insecticidal activity and has been used worldwide. Previous re-search has shown that environmental DM poses toxicity risks to aquatic animals. However, there is a lack of research assessing the potential threat of DM residual in feed ingredients. Since DM is a lipo-philic insecticide, it is also unknown if variations in dietary and body lipid levels will influence the toxicity and residues of DM. A six-week feeding trial was done to evaluate the toxicity of DM in Litopenaeus vannamei and explore the relationships between dietary lipid levels and DM levels. Six different diets were formulated with two lipid levels (6.96%, 10.88%) and three DM levels (0.2 mg(Symbol Presented)kg–1, 1 mg(Symbol Presented)kg–1, 5mg(Symbol Presented)kg–1), namely LF0.2, LF1, LF5, HF0.2, HF1, HF5, respectively. Each diet was assigned to three tanks (40 shrimp per tank, average weight 0.38±0.00g). The growth of shrimp was reduced as the dietary DM levels increased. When shrimp were fed a diet containing a high dose of DM, a reduction in their antioxidant capacity was also observed. Enzyme activity and gene ex-pression related to lipid metabolism in hepatopancreas and hemolymph indicated a significant interac-tion between dietary lipid levels and DM in the lipid metabolism of shrimp. The terms of detoxifica-tion-related genes (gst, sult, cyp1a1) were upregulated in shrimp fed the high-dose DM. Additionally, the presence of DM in the diet severely harmed the hepatopancreas and intestinal histological mor-phology. DM in the diet increased the susceptibility of shrimp to pathogens and induced gut micro-biota dysbiosis, disrupting the balance of inter-species interactions. DM was not detected in the mus-cle and hepatopancreas of the shrimp after six weeks of exposure. In conclusion, the presence of DM in feed reduced the growth performance and antioxidant capacity of shrimp, damaging intestinal health. DM was rapidly metabolized by shrimp. ? 2024, The Authors. All rights reserved.