文献类型：期刊文献

英文题名：Dietary chitosan oligosaccharides alleviate heat stress-induced intestinal oxidative stress and inflammatory response in yellow-feather broilers

作者：Lan, Ruixia[1];Li, Yaxuan[1];Chang, Qingqing[1];Zhao, Zhihui[1]

机构：[1]Guangdong Ocean Univ, Dept Anim Sci, Coll Coastal Agr Sci, Zhanjiang 524088, Peoples R China

年份：2020

卷号：99

期号：12

起止页码：6745

外文期刊名：POULTRY SCIENCE

收录：SCI-EXPANDED(收录号：WOS:000595168100048)、、Scopus(收录号：2-s2.0-85093963393)、WOS

基金：Financial support provided by program for scientific research start-up funds of Guangdong Ocean University (101402/R18005), College Students' Innovative Entrepreneurial Training Plan Program (S202010566030), and Key Platform Project of Innovation strong school Engineering by Department of Education of Guangdong Province (2018302) is gratefully acknowledged.

语种：英文

外文关键词：chitosan oligosaccharide; heat stress; intestinal oxidative status; intestinal inflammation; yellow-feather broiler

外文摘要：The purpose of this study was to evaluate the effects of chitosan oligosaccharides (COS) on intestinal permeability, morphology, antioxidant status, and inflammatory response in heat-stressed broilers. A total of 108 thirty -five-day-old Chinese yellow-feather broilers (body weight 470.31 +/- 13.15 g) were randomly allocated to 3 dietary treatments as follows: CON group, basal diet and raised under normal temperature (24 degrees C); HS group, basal diet and raised under cycle heat stress (34 degrees C from 10:00-18:00 and 24 degrees C for the rest time); HSC group, basal diet with 200 mg/kg COS supplementation and raised under cycle heat stress. Each treatment had 6 replication pens and 6 broilers per pen. Compared with the CON group, heat stress decreased (P < 0.05) the relative weight of duodenum and jejunum; the relative length and villus height (VH) of duodenum, jejunum, and ileum; the ileum VH to crypt depth ratio; duodenum mucosal catalase (CAT) activity; and jejunum mucosal glutathione peroxidase (GSH-Px) and CAT activity, whereas it increased (P < 0.05) serum diamine oxidase (DAO) activity and D-lactate acid (D-LA) content, duodenum and jejunum mucosal malondialdehyde (MDA) and interleukin-1 beta (IL-1 beta) content, and ileum mucosal tumor necrosis factor-alpha content. Compared to the HS group, dietary COS supplementation increased (P < 0.05) the relative length of duodenum, jejunum, and ileum; the VH of jejunum and ileum; and duodenum and jejunum mucosal GSH-Px activity, whereas it decreased (P < 0.05) serum DAO activity and D-LA concentration and duodenum and jejunum mucosal MDA and IL-1 beta content. These results suggested that dietary COS supplementation had beneficial effects on intestinal morphology by increasing jejunum and ileum VH; permeability by decreasing serum DAO activity and D-LA content; antioxidant capacity by decreasing duodenum and jejunum mucosal MDA content and by increasing duodenum and jejunum GSH-Px activity; and inflammatory response by decreasing duodenum and jejunum mucosal IL-1 beta content.