文献类型：期刊文献

英文题名：Mussel-Inspired Catechol-Functionalized Hydrogels and Their Medical Applications

作者：Quan, Wei-Yan[1];Hu, Zhang[1];Liu, Hua-Zhong[1];Ouyang, Qian-Qian[1];Zhang, Dong-Ying[1];Li, Si-Dong[1];Li, Pu-Wang[2];Yang, Zi-Ming[2]

机构：[1]Guangdong Ocean Univ, Dept Appl Chem, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, Key Lab Trop Crop Prod Proc, Minist Agr & Rural Affairs, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

年份：2019

卷号：24

期号：14

外文期刊名：MOLECULES

收录：SCI-EXPANDED(收录号：WOS:000482303000069)、、Scopus(收录号：2-s2.0-85069629500)、WOS

基金：Guangdong Provincial Natural Science Foundation of China (2016A030308009), Project of Science and Technology Plan of Guangdong Province (2017A010103023), Project of Enhancing School with Innovation of Guangdong Ocean University (2017KTSCX090), Graduate Education Innovation Program of Guangdong Ocean University (201829), and Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (1630122017011).

语种：英文

外文关键词：mussel adhesive protein; catechol; hydrogel; medical application

外文摘要：Mussel adhesive proteins (MAPs) have a unique ability to firmly adhere to different surfaces in aqueous environments via the special amino acid, 3,4-dihydroxyphenylalanine (DOPA). The catechol groups in DOPA are a key group for adhesive proteins, which is highly informative for the biomedical domain. By simulating MAPs, medical products can be developed for tissue adhesion, drug delivery, and wound healing. Hydrogel is a common formulation that is highly adaptable to numerous medical applications. Based on a discussion of the adhesion mechanism of MAPs, this paper reviews the formation and adhesion mechanism of catechol-functionalized hydrogels, types of hydrogels and main factors affecting adhesion, and medical applications of hydrogels, and future the development of catechol-functionalized hydrogels.