文献类型：期刊文献

英文题名：Ameliorative effects of oyster (Crassostrea hongkongensis) protein hydrolysate on age-induced cognitive impairment via restoring glia cell dysfunction and neuronal injured in zebrafish

作者：Zhu, Guo-Ping;Zhang, Chao-Hua[1];Qin, Xiao-Ming;Cao, Wen-Hong;Zheng, Hui-Na;Gao, Jia-Long

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China; Natl Res & Dev Branch Ctr Shellfish Proc Zhanjian, Zhanjiang, Peoples R China; Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China; Guangdong Prov Engn Lab Marine Biol Prod, Zhanjiang 524088, Peoples R China; Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Zhanjiang 524088, Peoples R China

年份：2021

卷号：85

外文期刊名：JOURNAL OF FUNCTIONAL FOODS

收录：SCI-EXPANDED(收录号：WOS:000687229100005)、、WOS

基金：This work was supported by the Applied Science and Technology Research and Development Project of Guangdong Province (grant no. 2016B020235002) , the Modern Agro-industry Technology Research System of China (grant no. CARS-49) and the Project of Enhancing School with Innovation of Guangdong Ocean University (grant no. GDOU2017052606) and Guangdong higher education institution inno-vative team of high value processing and utilization of aquatic products (grant no. GDOU2016030503) .

语种：英文

外文关键词：Oyster; Aged-zebrafish; Cognitive impairment; T-maze behaviour; Glia cell; Neuronal

外文摘要：Cognitive impairment caused by aging is a global public health problem. The 5-8 kDa ultrafiltration fraction of oyster (Crassostrea hongkongensis) protein hydrolysate (OPU) could ameliorate learning and memory in aged zebrafish, however the mechanism is still unclear. In this paper OPU was applied to explore the mechanism of reducing cognitive impairment of aged zebrafish. The OPU significantly ameliorated behavior in aged zebrafish. It reversed age-induced low antioxidant activity, high lipid peroxidation, microglial activation, and production of inflammatory cytokines, such as IL-1 beta, TNF-alpha and CD11b. It could improve age-induced suppressive astrocyte biomarkers and associated BDNF-TrkB signaling because it increased the expression of gfap, bdnf, trkB and psd95. OPU consumption could reverse age-induced neuronal loss and apoptosis, increase the neurotransmitters (Ach and r-GABA). The results demonstrated that OPU could ameliorate age-induced cognitive impairment. It may be a good base material to develop a related health food for the elderly.