文献类型：期刊文献

英文题名：Theragra chalcogramma Hydrolysates, Rich of Fragment Gly-Leu-Pro-Ser-Tyr-Thr, Ameliorate Alcohol-Induced Cognitive Impairment via Attenuating Neuroinflammation and Enhancing Neuronal Plasticity in Sprague-Dawley Rats

作者：Xu, Defeng[1]; Zhao, Mouming[2]

机构：[1] College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Labora-tory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology Research Center of Marine Food, Guangdong Province, Zhanjiang, 524088, China; [2] School of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, China

年份：2022

卷号：70

期号：39

起止页码：12513

外文期刊名：Journal of Agricultural and Food Chemistry

收录：EI(收录号：20224012842163)、Scopus(收录号：2-s2.0-85139206405)

语种：英文

外文关键词：Brain - Cell death - Rats

外文摘要：Chronic alcohol abuse induces the cognitive deficits and is associated with low-grade inflammation and neurodegeneration. Currently, by virtue of the immunomodulatory and neuroprotective properties, nutrients represent a promising strategy to attenuate cognitive impairments. We previously prepared the hydrolysates from Theragra chalcogramma skin (TCH), and this study aims to evaluate the neuroprotection of TCH on alcohol-induced cognitive impairment (AICI) and to elucidate the associated mechanism. Behavioral results showed that TCH effectively ameliorated AICI and this amelioration was highly associated with the decrease of IL-1β and the increase of BDNF, CREB, and PSD95 in AICI rats (P ? 2022 American Chemical Society.