文献类型：期刊文献

英文题名：Antioxidant and Antitumor Activity of a Crude Glycosaminoglycan Extracted from Sanguinolaria acuta

作者：Fan, Xiuping[1,3];Qin, Xiaoming[1,3];Wu, Caie[2]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Nanjing Forestry Univ, Coll Light Ind & Food Engn, Nanjing 210037, Jiangsu, Peoples R China;[3]Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China

年份：2018

卷号：20

期号：10

起止页码：2349

外文期刊名：INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY

收录：SCI-EXPANDED(收录号：WOS:000446491000028)、、WOS

基金：This work was financially supported by special funds for the construction of modern agricultural industrial technology system in China (No. CARS-49).

语种：英文

外文关键词：Oxidative stress; Antitumor activity; D-galactose induced aging model; Free radicals; Glycosaminoglycan from Sanguinolaria acuta (SAG-1)

外文摘要：Sanguinolaria acuta is a kind of delicious sea food in China and used as drugs. The antioxidant and antitumor activities of a crude glycosaminoglycan from S. acuta (SAG-1) were investigated. SAG-1 had the scavenging effect to free radicals. The IC50 value of diphenyl-picryl hydrazide (DPPH), hydroxyl radicals, and superoxide free radicals were 8.23, 12.2, and 13.2 mg/mL, respectively. The 10 mg/mL SAG-1 inhibition rate of lipid peroxidation of mice livers in vitro was 39.8%. In vivo, when compared with the normal mice group, D-galactose-induced aging mouse model group showed lower superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidases (GPX) activities in serum, liver, and kidney; and higher malondialdehyde (MDA) concentration (P<0.05). However, when 200 mg/kg.d SAG-1 was added to the aging mice, which showed an increased SOD and CAT activity in liver, kidney and GPX activity in serum, liver (P<0.05). The MDA concentration decreased significantly in the three tissues (P<0.05). The results showed that SAG-1 reduced the oxidative stress in aging mice and had the similar effect with Vc. In vitro, SAG-1 showed inhibitory effect on the proliferation of HeLa and CNE-2Z tumor cells. These findings indicate that the crude polysaccharide derived from S. acuta possesses antioxidative and antitumor activity, and may be used as a natural antioxidant. (C) 2018 Friends Science Publishers