文献类型：期刊文献

英文题名：Nature-inspired oligosaccharides: plant and algal routes to human milk functionality

作者：Cheong, Kit-Leong[1]; Chen, Wenjie[1]; Li, Jiajing[1]; Zhong, Hai-Jing[2]; Wang, Dongju[3]; Zhong, Saiyi[1]

机构：[1] College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang, China; [2] State Key Laboratory of Bioactive Molecules and Druggability Assessment, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education [MOE] of China, School of Pharmacy, Jinan University, Guangzhou, China; [3] Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, China

年份：2026

外文期刊名：Critical Reviews in Food Science and Nutrition

收录：EI(收录号：20260219869700)、Scopus(收录号：2-s2.0-105026716721)

语种：英文

外文关键词：Adhesion - Biomimetics - Biomolecules - Brain - Metabolites - Pathogens - Plants (botany)

外文摘要：Human milk oligosaccharides (HMO) shape early-life health by guiding microbiome assembly, fortifying the mucosal barrier, calibrating immune responses by enhancing secretory IgA at mucosal surfaces, blocking pathogen adhesion, and influencing the microbiota–gut–brain axis. Direct deployment of structurally diverse HMO at population scale remains constrained by manufacturing complexity and cost. This review examines "nature-inspired" oligosaccharides derived from plant and marine algal as affordable, scalable HMO mimetics, mapping chemistry to biology across five functional domains: microbiota architecture & metabolism, inhibition of pathogen adhesion via glycan decoy mechanisms, immune education, mucosal barrier enhancement and gut-brain regulation. We synthesize and critically appraise evidence on plant-derived fructo-, xylo-, and mannan-oligosaccharides, as well as on red-algal agaro-oligosaccharides and brown-algal fuco-oligosaccharides. Although these glycans do not fully replicate individual HMO structures, they can exhibit convergent mechanisms: selective fueling of saccharolytic consortia to produce functional metabolites (SCFAs), multivalent fucose-rich decoying of viral/bacterial adhesins, dendritic-cell/T- and B-cell tuning, epithelial junction and mucus programs, and neuroactive/metabolite signaling along the gut–brain axis. Framed as functional mimicry rather than strict structural emulation, plant and marine oligosaccharides emerge as promising "glycobiotics" to deliver HMO-like benefits across the lifespan, with opportunities for precision, personalized, and sustainable formulations guided by multi-omics and glycoinformatics. ? 2026 Taylor & Francis Group, LLC.