文献类型：期刊文献

英文题名：Biocompatible quaternized chitosan-based nanocomposite hydrogels with antibacterial and rapid hemostatic properties

作者：Zhang, Juanni[1];Mohd Said, Farhan[1];Lv, Ruixue[2];Daud, Nur Fathin Shamirah[1];Jing, Zhanxin[2]

机构：[1]Univ Malaysia Pahang Al Sultan Abdullah, Fac Chem & Proc Engn Technol, Lebuh Persiaran Tun Khalil Yaakob, Kuantan 26300, Pahang, Malaysia;[2]Guangdong Ocean Univ, Coll Chem & Environm, Zhanjiang 524088, Guangdong, Peoples R China

年份：2025

卷号：15

期号：37

起止页码：30202

外文期刊名：RSC ADVANCES

收录：SCI-EXPANDED(收录号：WOS:001556638800001)、、EI(收录号：20253519060990)、Scopus(收录号：2-s2.0-105014150949)、WOS

基金：This study was supported by university grant PGRS220355 (Malaysia) and Science and Technology Plan Project of Zhanjiang City, China (Project No. 2021A05049).

语种：英文

外文关键词：Amides - Biocompatibility - Biomechanics - Chitosan - Escherichia coli - Hydrogels - Medical applications - Morphology - Nanocomposites - Structure (composition) - Swelling

外文摘要：In this study, we developed a quaternized chitosan-based nanocomposite hydrogel by combining dual-network and nanocomposite technology. Firstly, quaternized chitosan (QCS) and chitin nanowhiskers (ChWs) were synthesized and characterized. The quaternized chitosan-based nanocomposite hydrogels were constructed by the radical polymerization of acrylic acid (AA) and acrylamide (AM) and the subsequent cooling process in the presence of QCS, ChWs, and Zn2+. The chemical structure and morphology of the synthesized hydrogels were analyzed using FT-IR and SEM, revealing that the nanocomposite hydrogels have a remarkable three-dimensional network structure. The effects of QCS, ChWs, and Zn2+ content on the hydrogel's physical and biological properties were systematically investigated. The swelling behavior, mechanical strength, and antibacterial performance of quaternized chitosan-based nanocomposite hydrogels can be effectively modulated by varying their composition. An increase in QCS content led to a notable enhancement in mechanical properties. Specifically, the hydrogel containing 25% QCS exhibited a tensile strength of 391.9 kPa and an elongation at break of 495%. The increased QCS and Zn2+ contents significantly improved the antibacterial properties of the nanocomposite hydrogels. The antibacterial rate against E. coli and S. aureus could reach up to 99%. Furthermore, the QCS-based nanocomposite hydrogels demonstrated good biocompatibility and rapid hemostatic ability. We expect that this simple strategy combining nanocomposite technology and dual-network technology will enrich the avenues for exploring hydrogels with excellent mechanical strength, antibacterial activity, and hemostatic performance for biomedical applications such as wound management, hemostatic materials, and infection control.