文献类型：期刊文献

英文题名：Protective Effects of Squid Ink Extract Towards Hemopoietic Injuries Induced by Cyclophosphamine

作者：Zhong, Jie-Ping[1];Wang, Guang[2];Shang, Jiang-Hua[3];Pan, Jiang-Qiu[2];Li, Kun[1];Huang, Yan[1];Liu, Hua-Zhong[1]

机构：[1]Guangdong Ocean Univ, Modern Biochem Ctr, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[3]Chinese Acad Agr Sci, Buffalo Res Inst, Nanning 530001, Peoples R China

年份：2009

卷号：7

期号：1

起止页码：9

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000264557700002)、、Scopus(收录号：2-s2.0-63049128992)、WOS

基金：We thank Proferssors Rundi Ma and Lijian Yu from the Laboratory of Marine Material Medica in Guangdong Ocean University for providing instructional assistance. We are grateful to Xiangjun Tu and Jinshu Xie from Zhanjiang Huatai Hospital in Guangdong Province for their assistance in the detection of peripheral blood profiles, and we also thank Shubing Guan, Yizhong Guo, Zhilun Chen, Yonglian Li and Xiaoming Zhan for assistance in this investigation. This work was supported by the project of Science & Technology Plan in Guangdong Province (2008B021100014) and grant from Natural Science Foundation of Guangdong Ocean University (0812171).

语种：英文

外文关键词：Squid ink; cyclophosphamine; hemopoiesis; mice

外文摘要：To investigate the protective effects of squid ink in chemotherapy, BALB/c mice were used as animal models of injuries induced by cyclophosphamine, a well known chemotherapeutic drug. The mice were randomly divided into five groups with the same number of males and females in each group. At the end of the experiment, animals were sacrificed to investigate organ indexes and antioxidant ability of the spleen, peripheral blood profile and quantities of bone marrow nucleated cells. Results showed that the hemopoietic function of mice was injured by cyclophosphamine, as indicated by decreases of contents of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), while platelets were not affected (P>0.05), as well as modification of organ indexes (P<0.05) and spleen antioxidant ability (P<0.05 or P<0.01), whereas sepia extract markedly increased the levels of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P<0.01), but not platelets (P>0.05), and reversed the effects of cyclophosphamine on organ indexes and antioxidant ability of spleen (P<0.01 or P<0.05). In addition, squid ink extract did not change marrow hemopoiesis but improved the antioxidant ability of spleen in the animals. The data suggest that squid ink extract can protect the hemopoietic system from chemotherapeutic injury and could be employed to develop cell-protective drugs for use in clinical treatment of tumours.