文献类型：专著

英文题名：Functional foods and Parkinson's disease: A focus on omega-3 fatty acids

作者：Li P.; Song C.

机构：[1]Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China;[2]Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China;[3]Marine Medicine Research and Development Center, Shenzhen Institute, Guangdong Ocean University, Shenzhen, China

出版社：Elsevier

出版日期：0

页数：11

纸书定价：0

isbn号：978-032391747-6; 978-032397266-6

语种：英文

外文关键词：Neuroinflammation; Neuroprotective; Omega-3 polyunsaturated fatty acids; Oxidative stress; Parkinson's disease

外文摘要：Parkinson's disease (PD) is characterized by deterioration of the nigrostriatal system and intracellular inclusions containing aggregates of α-synuclein. Mounting evidence suggests aging, ethnicity, geography, genetic susceptibility, and environmental factors may cause PD. Recently, growing evidence has shown that neuroinflammation is involved in the pathogenesis of PD. However, none of these factors induces PD independently. Current clinical pharmacotherapies only temporarily relieve the symptoms of PD, accompanied by many side effects. Hence, strategies to prevent or delay PD pathology may be well suited to lifestyle changes like functional foods to ameliorate the major symptoms and reverse disease progress. Functional food supplementation especially polyunsaturated fatty acids (PUFAs) may have potential in the management of PD. PUFAs, especially the omega(n)-3, are an important component of the cell membrane. Together by competing with the production of n-6 PUFAs, which are the precursors of inflammatory mediators, n-3 PUFAs can regulate neurotransmission, microglia, astrocyte activities, and immune function, thereby improving mood and cognition. With regards to the hypotheses of PD, PUFAs may be promising for delaying or preventing PD by inhibiting proinflammatory cytokine release, promoting neurotrophic factor production, recovering the mitochondrial function and membrane fluidity, decreasing the levels of ROS and NO production and maintaining α-synuclein proteostasis, calcium homeostasis, axonal transport, as well as endoplasmic reticulum stress. This chapter mainly introduces and analyzes the effect of one of the functional foods, n-3 PUFA treatment on PD-like behavioral and neuropathological abnormalities in clinical patients and different cellular and animal models of PD. ? 2024 Elsevier Inc. All rights reserved.