文献类型：期刊文献

英文题名：Preventive Effects of Three Polysaccharides on the Oxidative Stress Induced by Acrylamide in a Saccharomyces cerevisiae Model

作者：Lin, Zhen[1];Zhang, Yu[1];Li, Fangping[1];Tan, Xiaohui[1];Luo, Ping[1];Liu, Huazhong[1]

机构：[1]Guangdong Ocean Univ, Coll Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2020

卷号：18

期号：8

外文期刊名：MARINE DRUGS

收录：SCI-EXPANDED(收录号：WOS:000564585700001)、、Scopus(收录号：2-s2.0-85088886111)、WOS

基金：This work was supported by the Natural Science Foundation of Guangdong Province, China (2019A1515011102), and the Science and Technology Project on Special Fund for Public Welfare Research and Ability Construction of Guangdong Province, China (2017A010105010).

语种：英文

外文关键词：acrylamide; polysaccharides from Sepia esculenta ink; fucoidan from Laminaria japonica; polysaccharides from Eleocharis tuberosa peel; oxidative stress; Saccharomyces cerevisiae

外文摘要：Saccharomyces cerevisiaewas used as a model to explore the preventive effect of two marine polysaccharides separately derived fromSepia esculentaink (SIP) andLaminaria japonica(FL) as well as one terrestrial polysaccharides fromEleocharis tuberosapeel (WCPP) on toxic injury induced by acrylamide (AA). The growth of yeast was evaluated by kinetics indexes including doubling time, lag phase and maximum proliferation density. Meanwhile, intracellular redox state was determined by contents of MDA and GSH, and SOD activity. The results showed that AA inhibited yeast growth and destroyed the antioxidant defense system. Supplement with polysaccharides, the oxidative damage of cells was alleviated. According to the growth recovery of yeast, FL and WCPP had similar degree of capacity against AA associated cytotoxicity, while SIP was 1.5 similar to 2 folds as strong as FL and WCPP. SIP and FL significantly reduced production of MDA by AA administration. Moreover, SIP, FL and WCPP increased SOD activity and repressed GSH depletion caused by AA.