文献类型：期刊文献

英文题名：Anserine beneficial effects in hyperuricemic rats by inhibiting XOD, regulating uric acid transporter and repairing hepatorenal injury

作者：Chen, Ming[1];Ji, Hongwu[1,2,3,4,5];Song, Wenkui[1];Zhang, Di[1];Su, Weiming[1,2];Liu, Shucheng[1,2,3,4,5,6]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[2]Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[3]Guangdong Prov Engn Lab Marine Biol Prod, Zhanjiang 524088, Peoples R China;[4]Guangdong Prov Engn Technol Res Ctr Marine Food, Zhanjiang 524088, Peoples R China;[5]Key Lab Adv Proc Aquat Prod Guangdong Higher Educ, Zhanjiang 524088, Peoples R China;[6]Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China

年份：2022

卷号：13

期号：18

起止页码：9434

外文期刊名：FOOD & FUNCTION

收录：SCI-EXPANDED(收录号：WOS:000840913200001)、、EI(收录号：20223612689405)、Scopus(收录号：2-s2.0-85137108843)、WOS

基金：This work was co-supported by the National Key Research and Development Program (2019YFD0902004) and the Guangdong Innovation Team of Seafood Green Processing Technology (2019KCXTD011).

语种：英文

外文关键词：Amino acids - Gene expression - Phosphatases - Potassium compounds - Superoxide dismutase - Urea

外文摘要：This study aims to investigate the anti-hyperuricemia effect and mechanism of anserine in hyperuricemic rats. Hyperuricemic rats were induced with a combination of 750 mg per kg bw d potassium oxazinate (PO) and 200 mg per kg bw d hypoxanthine for a week, and the rats were separately orally administered anserine (20, 40, 80 mg kg(-1)) and allopurinol (10 mg kg(-1)) for three weeks. The results show that the content of serum uric acid (SUA) decreased by approximately 40% and 60% after the intervention of anserine and allopurinol, respectively. The activity of superoxide dismutase (SOD) was increased and the levels of malondialdehyde (MDA), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) were significantly decreased in the anserine groups. After the administration of anserine, the contents of blood urea nitrogen (BUN) and creatinine (Cr) were reduced in the kidney, and the levels of the proinflammatory cytokines IL-1 beta, IL-6 beta, TNF-alpha and TGF-beta and inflammatory cell infiltration were reduced in both the liver and kidney. Moreover, the gene expressions of xanthine oxidase (XOD), renal urate transporter 1 (URAT1) and glucose transporter type 9 (GLUT9) were downregulated by anserine administration, and the gene expressions of ATP-binding cassette transporter G2 (ABCG2), organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) were upregulated at the same time. These findings suggest that hepatorenal injury was repaired by anserine, which further regulated the expression of hepatic XOD and renal URAT1, GLUT9, ABCG2, OAT1 and OAT3 to relieve hyperuricemia in rats.