文献类型：期刊文献

英文题名：A sodium alginate-based sustained-release IPN hydrogel and its applications

作者：Zou, Zuhao[1];Zhang, Bijun[1];Nie, Xiaoqin[1];Cheng, Yu[1];Hu, Zhang[1];Liao, Mingneng[1];Li, Sidong[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China

年份：2020

卷号：10

期号：65

起止页码：39722

外文期刊名：RSC ADVANCES

收录：SCI-EXPANDED(收录号：WOS:000584324000039)、、EI(收录号：20204609477929)、Scopus(收录号：2-s2.0-85095732034)、WOS

基金：We gratefully acknowledge the financial support of the Project of Enhancing School with Innovation of Guangdong provincial (530003002057), the Project of Zhanjiang city non-funded (2019B01049), the Project of Enhancing School with Innovation of Guangdong Ocean University (CXXL2019295), and the Project of Enhancing School with Innovation of Guangdong Ocean University (CXXL2019303).

语种：英文

外文关键词：Biocompatibility - Drug products - Hydrogels - Interpenetrating polymer networks - Sodium - Sodium alginate - Targeted drug delivery

外文摘要：Interpenetrating polymer network (IPN) hydrogels are crosslinked by two or more polymer networks, providing free volume space in the three-dimensional network structure, and providing conditions for the sustained and controlled release of drugs. The IPN hydrogels based on the natural polymer sodium alginate can form a stable porous network structure. Due to its excellent biocompatibility, the loaded drug can be sustained to the maximum extent without affecting its pharmacological effect. Sodium alginate-based IPN hydrogels have broad application prospects in the field of sustained and controlled drug release. This paper begins with an overview of the formation of alginate-based IPN hydrogels; summarizes the types of alginate-based IPN hydrogels; and discusses the pharmaceutical applications of alginate-based IPN hydrogels. We aim to give an overview of the research on IPN hydrogels based on sodium alginate in sustained and controlled drug release systems.