文献类型：期刊文献

英文题名：Docosahexaenoic Acid Promotes Cd Excretion by Restoring the Abundance of Parabacteroides in Cd-Exposed Mice

作者：Liao, Jianzhen[1];Bi, Siyuan[1,2];Fang, Zhijia[1];Deng, Qi[1];Chen, Yinyan[1];Sun, Lijun[1];Jiang, Yongqing[2,3];Huang, Linru[1];Gooneratne, Ravi[4]

机构：[1]Guangdong Ocean Univ, Key Lab Adv Proc Aquat Prod, Coll Food Sci & Technol, Res Ctr Marine Food,Guangdong Prov Key Lab Aquat P, Zhanjiang 524088, Peoples R China;[2]Shenzhen Jinyue Test Technol Co Ltd, Shenzhen 510100, Peoples R China;[3]Shenzhen Lvshiyuan Biotechnol Co Ltd, Shenzhen 510100, Peoples R China;[4]Lincoln Univ, Dept Wine Food & Mol Biosci, Lincoln 7647, New Zealand

年份：2023

卷号：28

期号：10

外文期刊名：MOLECULES

收录：SCI-EXPANDED(收录号：WOS:000997061300001)、、Scopus(收录号：2-s2.0-85160374287)、WOS

基金：This work was supported by the National Natural Science Foundation of China (No. 32172215) and the Natural Science Foundation of Guangdong Province (No. 2019A1515010809 and No. 2021A1515012443).

语种：英文

外文关键词：cadmium; gut microbiota; docosahexaenoic acid; cadmium excretion; Parabacteroides distasonis; succinic acid

外文摘要：As a common harmful pollutant, cadmium (Cd) can easily enter the human body through the food chain, posing a major threat to human health. Gut microbiota play a key role in Cd absorption. Docosahexaenoic acid (DHA) is thought to have a potential role in the treatment of Cd poisoning. This study investigated the therapeutic effect and mechanism of DHA in Cd-exposed mice from the perspective of the gut microbiota. The results showed that DHA significantly increased the Cd content in feces and decreased the Cd accumulation in the organs of mice. The gut microbiota results showed that DHA significantly restored the abundance of Parabacteroides in the gut microbiota of Cd-exposed mice. Parabacteroides distasonis (P. distasonis), a representative strain of the Parabacteroides, also showed Cd- and toxicity-reduction capabilities. P. distasonis significantly restored the gut damage caused by Cd exposure. At the same time, P. distasonis reduced the Cd content in the liver, spleen, lung, kidneys, gut, and blood to varying degrees and significantly increased the Cd content in feces. The succinic acid produced by P. distasonis plays an important role in promoting Cd excretion in Cd-exposed mice. Therefore, these results suggest that P. distasonis may have a potential role in DHA-mediated Cd excretion in Cd-exposed mice.