文献类型：期刊文献

英文题名：Preparation of norfloxacin-grafted chitosan antimicrobial sponge and its application in wound repair

作者：Cheng, Yu[1];Wang, Jiyuan[1];Hu, Zhang[1];Zhong, Saiyi[2];Huang, Na[1];Zhao, Yuntao[2];Tao, Yi[1];Liang, Youling[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China

年份：2022

卷号：210

起止页码：243

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000806366100004)、、EI(收录号：20242616391189)、Scopus(收录号：2-s2.0-85129958540)、WOS

基金：Acknowledgments This work was funded by Project of Science and Technology Plan of Zhanjiang (2019A01017 and 2020A01026) , Guangdong Basic and Applied Basic Research Foundation (2020A1515010366) , Guangdong Ocean University Undergraduate Innovation Team Project (CXTD2021020) , and Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) .

语种：英文

外文关键词：Chitosan; Norfloxacin; Wound healing; Antimicrobial activity

外文摘要：Trauma is one of the most common health issues in humans, and bacterial infection of the wound may result in many complications. In this paper, using 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) as a coupling agent, chitosan (CS) was grafted with norfloxacin (NF), an antibacterial agent, to prepare a CS-NF sponge by freezing-induced phase separation. The CS-NF sponge was characterized by ultra violet-visible spectroscopy, Fourier transform infrared spectroscopy, and scanning electron microscopy. Its porosity and water absorption ratio were determined, the antimicrobial activity was evaluated by inhibition zone assay, and its wound repair effect was investigated in a full-thickness cutaneous excisional wound animal model. The results showed that NF was successfully grafted onto CS, and the obtained CS-NF sponge had both a high porosity and water absorption ratio. The CS-NF sponge displayed significant antimicrobial activities in the inhibition zone assay. In vivo the CS-NF sponge exhibited a strong wound healing effect, with a wound healing rate close to 100% by day 15. Therefore, the CS-NF sponge is a novel promising wound-healing dressing for clinical practice.