文献类型：期刊文献

英文题名：Integrated transcriptomic and metabolomic analysis sheds new light on adaptation of Pinctada fucata martensii to short-term hypoxic stress

作者：Chen, Jiayi[1]; Qiu, Jinyu[1]; Yang, Chuangye[1,3,4,5]; Liao, Yongshan[3]; He, Maoxiao[2]; Mkuye, Robert[1]; Li, Junhui[1]; Deng, Yuewen[1,3,4,5]; Du, Xiaodong[1,3,4,5]

机构：[1] Fisheries College, Guangdong Ocean University, Zhanjiang, 524088, China; [2] CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; [3] Pearl Breeding and Processing Engineering Technology Research Centre of Guangdong Province, Zhanjiang, 524088, China; [4] Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy culture, Zhanjiang, 524088, China; [5] Guangdong Marine Ecology Early Warning and Monitoring Laboratory, Zhanjiang, 524088, China

年份：2023

卷号：187

外文期刊名：Marine Pollution Bulletin

收录：EI(收录号：20230113330767)、Scopus(收录号：2-s2.0-85145217031)

语种：英文

外文关键词：Amino acids - Biomineralization - Metabolism - Metabolites - Molluscs - Proteins

外文摘要：Analyses of the transcriptome and metabolome were conducted to clarify alterations of key genes and metabolites in pearl oysters following exposure to short-term hypoxic treatment. We totally detected 209 DEGs between the control and hypoxia groups. Enrichment analysis indicated the enrichment of GO terms including "oxidation-reduction process", "ECM organization", "chaperone cofactor-dependent protein refolding", and "ECM-receptor interaction" KEGG pathway by the DEGs. In addition, between the two groups, a total of 28 SDMs were identified, which were implicated in 13 metabolic pathways, such as "phenylalanine metabolism", "D-amino acid metabolism", and "aminoacyl-tRNA biosynthesis". Results suggest that pearl oysters are exposed to oxidative stress and apoptosis under short-term hypoxia. Also, pearl oysters might adapt to short-term hypoxic treatment by increasing antioxidant activity, modulating immune and biomineralization activities, maintaining protein homeostasis, and reorganizing the cytoskeleton. The results of our study help unveil the mechanisms by which pearl oysters respond adaptively to short-term hypoxia. ? 2022 Elsevier Ltd