文献类型：期刊文献

中文题名：肌纤维类型转化机制及其在畜禽生产中的调控作用

英文题名：Mechanisms of Muscle Fiber Type Transformation and Their Regulatory Roles in Livestock and Poultry Production

作者：唐雪颖[1,2];郭建超[3];莫兹源[1];闵力[1];张志飞[1];刘建营[3];李大刚[1];巨向红[2];童雄[1]

机构：[1]广东省农业科学院动物科学研究所,广州510640;[2]广东海洋大学滨海农业学院,湛江524088;[3]广东省农业技术推广中心,广州510520

年份：2026

卷号：53

期号：6

起止页码：3042

中文期刊名：中国畜牧兽医

外文期刊名：China Animal Husbandry & Veterinary Medicine

收录：北大核心2023、、北大核心

基金：国家重点研发计划项目子课题项目(2024YFD130010206);以农产品为单元的广东省现代农业产业技术体系创新团队建设项目(牛羊产业技术体系)(2024CXTD13);2024年省级乡村振兴战略专项资金广东农技服务轻骑兵重大农业技术乡村行推广项目(NJTG20240254);汕尾市科技计划项目(2023A016)。

语种：中文

中文关键词：畜禽生产;骨骼肌纤维;肌纤维类型转化;信号通路;基因;非编码RNA

外文关键词：livestock and poultry production;skeletal muscle fibers;muscle fiber type transformation;signal pathways;gene;non-coding RNA

中文摘要：骨骼肌肌纤维类型组成是决定畜禽产肉效率与肉品质的关键内在因素,其转化机制的解析对畜牧生产具有重要的理论与实践意义。笔者概述了基于不同生理收缩特性、代谢类型、酶组织化学特性及肌球蛋白重链(MyHC)亚型的肌纤维分类体系;重点分析了钙离子(Ca^(2+))/钙调蛋白激酶(CaMK)/钙调神经磷酸酶(CaN)、腺苷酸活化蛋白激酶(AMPK)/沉默信息调节因子1(SIRT1)/过氧化物酶体增殖物激活受体γ共激活因子-1α(PGC-1α)、丝裂原活化蛋白激酶(MAPK)、Wnt和磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)等核心信号通路参与肌纤维类型转化的分子机制;总结了生肌调节因子(MRFs)、退化样家族成员3(VGLL3)、肌肉生长抑制素(MSTN)等关键基因,以及微小RNA(miRNA)、长链非编码RNA(lncRNA)、环状RNA(circRNA)等非编码RNA在该调控网络中的作用;探讨了肌纤维类型组成对畜禽生长性能、肉品质(涵盖肌内脂肪、风味、持水力、肉色与嫩度)、肌肉疾病及热应激的综合影响;最后,笔者总结了非编码RNA(ncRNA)作用机制、调控网络的品种特异性等方面局限性,旨在为深入解析肌纤维类型转化的调控网络、推动畜禽分子育种实践,进而提升产业经济效益与可持续发展提供理论参考。

外文摘要：The composition of muscle fiber types in skeletal muscles is a crucial intrinsic factor determining the meat production efficiency and quality of livestock.The elucidation of the mechanism of this transformation has significant theoretical and practical significance for livestock production.The author outlines a classification system of muscle fibers based on different physiological contraction characteristics,metabolic types,enzyme histochemical properties,and myosin heavy chain(MyHC)subtypes;It focuses on analyzing the molecular mechanisms of muscle fiber type transformation involving core signaling pathways such as calcium ions(Ca^(2+))/calcineurin kinase(CaMK)/calcineurin,adenosine monophosphate-activated protein kinase(AMPK)/silent information regulator 1(SIRT1)/peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α),mitogen-activated protein kinase(MAPK),Wnt,and phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt)/mammalian target of rapamycin(mTOR);It summarizes key genes such as myogenic regulatory factors(MRFs),degeneration-like family member 3(VGLL3),and myostatin(MSTN),as well as non-coding RNAs such as microRNAs(miRNA),long non-coding RNAs(lncRNA),and circular RNAs(circRNA)in this regulatory network;It discusses the comprehensive effects of muscle fiber type composition on livestock growth performance,meat quality(including intramuscular fat,flavor,water-holding capacity,meat color and tenderness),muscle diseases and heat stress;Finally,the author summarized the limitations of the mechanism of action and the species-specificity of the regulatory networks of non-coding RNAs(ncRNAs),aiming to provide theoretical references for indepth analysis of the regulatory network of muscle fiber type transformation,promoting molecular breeding practices in livestock,and thereby enhancing the economic benefits and sustainable development of the industry.