文献类型：期刊文献

英文题名：Emerging nanolabels-based immunoassays: Principle and applications in food safety

作者：Pan, Ruiyuan[1];Li, Guoliang[1];Liu, Shucheng[3];Zhang, Xianlong[1];Liu, Jianghua[1];Su, Zhuoqun[1];Wu, Yongning[1,2]

机构：[1]Shaanxi Univ Sci & Technol, Sch Food & Biol Engn, Xian 710021, Peoples R China;[2]Chinese Acad Med Sci, China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Food Safety Res Unit 2019RU014, Beijing 100021, Peoples R China;[3]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang, Peoples R China

年份：2021

卷号：145

外文期刊名：TRAC-TRENDS IN ANALYTICAL CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000774056700004)、、EI(收录号：20214711193137)、Scopus(收录号：2-s2.0-85119275459)、WOS

基金：This work was supported by the National Natural Science Foundation of China (32022069 and 22076115), the Science and Technology Nova Plan of Shaanxi Province (2019KJXX-010), and the Youth Innovation Team of Shaanxi Universities (21JP020).

语种：英文

外文关键词：Nanolabels; Nanozymes; Immunoassay; Food contaminants

外文摘要：Food safety issues pose a serious threat to human health, and appropriate detection technologies can effectively ensure food safety. Immunoassay is the gold standard for highly sensitive detection of biochemical targets, providing a good platform for food contaminants detection. In immunoassay, the antibody or antigen conjugated labels are the most important units because they play roles to convert the information of target analytes to easily detected signal. Recently, various efforts have been paid into the label design to enhance the detection sensitivity and stability. Nanomaterials own advantages such as facile preparation, excellent stability, low cost and multi-category signal output, showing great potential as novel labels. Herein, we summarize the advances of nanolabels in immunoassays, covering nano-materials as nanozymes, direct signal indicators, enzyme carriers, etc. Moreover, applications of nanolabels-based immunoassays in the detection of food contaminants (pathogenic microorganisms, allergic proteins, biotoxins, and others) are comprehensively concluded. Finally, challenges and perspectives on the future trends are also proposed. (C) 2021 Elsevier B.V. All rights reserved.