文献类型：期刊文献

英文题名：Zebrafish models in neuropsychopharmacology and CNS drug discovery

作者：Khan, Kanza M.[1];Collier, Adam D.[1,2];Meshalkina, Darya A.[2,3];Kysil, Elana V.[3];Khatsko, Sergey L.[4];Kolesnikova, Tatyana[4];Morzherin, Yury Yu[4];Warnick, Jason E.[2,5];Kalueff, Allan V.[2,3,4,6];Echevarria, David J.[1,2]

机构：[1]Univ Southern Mississippi, Dept Psychol, Hattiesburg, MS 39406 USA;[2]Int Zebrafish Neurosci Res Consortium ZNRC, Slidell, LA USA;[3]St Petersburg State Univ, Inst Translat Biomed, St Petersburg, Russia;[4]Ural Fed Univ, Ekaterinburg, Russia;[5]Arkansas Tech Univ, Dept Behav Sci, Russellville, AR 72801 USA;[6]Guangdong Ocean Univ, Res Inst Marine Drugs & Nutr, Coll Food Sci & Technol, Zhanjiang, Guangdong, Peoples R China

年份：2017

卷号：174

期号：13

起止页码：1925

外文期刊名：BRITISH JOURNAL OF PHARMACOLOGY

收录：SSCI(收录号：WOS:000403299900005)、SCI-EXPANDED(收录号：WOS:000403299900005)、、Scopus(收录号：2-s2.0-85017091455)、WOS

基金：The study was coordinated through the International Zebrafish Neuroscience Research Consortium (ZNRC), and this collaboration was funded by St. Petersburg State University, Ural Federal University and Guangdong Ocean University. A.V.K. is the Chair of ZNRC, and his research is supported by the Russian Foundation for Basic Research (RFBR) grant 16-04-00851.

语种：英文

外文摘要：Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.