文献类型：期刊文献

英文题名：Chitosan hydrogel in combination with marine peptides from tilapia for burns healing

作者：Ouyang, Qian-Qian[1,3];Hu, Zhang[1];Lin, Zhen-Peng[2];Quan, Wei-Yan[1];Deng, Yi-Feng[2];Li, Si-Dong[1];Li, Pu-Wang[4];Chen, Yu[5]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Guangdong Med Univ, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524001, Peoples R China;[3]Guangdong Ocean Univ, Sch Ocean & Meteorol, Zhanjiang 524088, Peoples R China;[4]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China;[5]Beijing Inst Technol, Sch Mat Sci & Engn, Beijing 100081, Peoples R China

年份：2018

卷号：112

起止页码：1191

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000430522400140)、、Scopus(收录号：2-s2.0-85042193884)、WOS

基金：We acknowledge the financial support from Project of Science and Technology Plan of Guangdong Province (2015A020216019, 2017A010103023), Guangdong Provincial Natural Science Foundation of China (2016A030308009), Project of Enhancing School With Innovation of Guangdong Ocean University (GDOU2013050221, GDOU2016050255) and Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences (No. 1630122017009).

语种：英文

外文关键词：Chitosan; Marine peptides; Burns healing

外文摘要：The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing. (C) 2018 Elsevier B.V. All rights reserved.