文献类型：期刊文献

英文题名：Characteristics of Antisense Transcript Promoters and the Regulation of Their Activity

作者：Lin, Shudai[1,2,3];Zhang, Li[1,2,3,4];Luo, Wen[1,2,3];Zhang, Xiquan[1,2,3]

机构：[1]South China Agr Univ, Coll Anim Sci, Dept Anim Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China;[2]Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou 510642, Guangdong, Peoples R China;[3]Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China;[4]Guangdong Ocean Univ, Coll Agr, Zhanjiang 524088, Peoples R China

年份：2016

卷号：17

期号：1

外文期刊名：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

收录：SCI-EXPANDED(收录号：WOS:000374583800009)、、Scopus(收录号：2-s2.0-84951834563)、WOS

基金：This work was supported by the Chinese Postdoctoral Science Foundation (2012M521611, 2013T60808), the National Natural Science Foundation (31301958), the Guangdong Provincial Natural Science Foundation (S2013010013382) and the China Agriculture Research System (CARS-42-G05). The funders played no role in the study design, the decision to publish, or in the preparation of the manuscript.

语种：英文

外文关键词：antisense promoter; location; characteristics; activity; influencing factors

外文摘要：Recently, an increasing number of studies on natural antisense transcripts have been reported, especially regarding their classification, temporal and spatial expression patterns, regulatory functions and mechanisms. It is well established that natural antisense transcripts are produced from the strand opposite to the strand encoding a protein. Despite the pivotal roles of natural antisense transcripts in regulating the expression of target genes, the transcriptional mechanisms initiated by antisense promoters (ASPs) remain unknown. To date, nearly all of the studies conducted on this topic have focused on the ASP of a single gene of interest, whereas no study has systematically analyzed the locations of ASPs in the genome, ASP activity, or factors influencing this activity. This review focuses on elaborating on and summarizing the characteristics of ASPs to extend our knowledge about the mechanisms of antisense transcript initiation.