文献类型：期刊文献

英文题名：Synthesis of gentamicin-grafted-chitosan with improved solubility and antibacterial activity

作者：Yan, Tingting[1,3];Li, Chengpeng[1];Ouyang, Qianqian[1];Zhang, Dongying[1];Zhong, Qingkun[1];Li, Puwang[2];Li, Sidong[1];Yang, Ziming[2];Wang, Tao[4];Zhao, Qingxia[4]

机构：[1]Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China;[3]Guangdong Ocean Univ, Sch Ocean & Meteorol, Zhanjiang 524088, Peoples R China;[4]Zhengzhou Univ, Sch Nursing, Zhengzhou 450001, Henan, Peoples R China

年份：2019

卷号：137

起止页码：38

外文期刊名：REACTIVE & FUNCTIONAL POLYMERS

收录：SCI-EXPANDED(收录号：WOS:000463123200005)、、EI(收录号：20190506454782)、Scopus(收录号：2-s2.0-85060765531)、WOS

基金：We acknowledge the financial support from Project of Science and Technology Plan of Guangdong Province (2015A020216019, 2017A010103023), Guangdong Provincial Natural Science Foundation of China (2018A030307015), Project of Enhancing School With Innovation of Guangdong Ocean University (GDOU2013050221, GDOU2016050255), National Natural Science Foundation of China (No.81773175 and No.11704343), China Postdoctoral Science Foundation (No. 2018M630839).

语种：英文

外文关键词：Gentamicin; Chitosan; Antibacterial activity; Water solubility

外文摘要：Due to superior properties, chitosan (CS) has been widely applied in health field. However its acid-solubility and poor antimicrobial activity compromise its safety and applications, respectively. To enhance its water-solubility and antimicrobial activity, gentamicin-grafted-chitosan (GT-CS) is synthesized for the first time, which is then confirmed by various characteristic methods and the graft ratio for gentamicin is about 22.1%. Particularly, it is the first study, disclosing there are degradation and crosslinking involved simultaneously during CS oxidation. Furthermore, GT-CS shows greatly improved water solubility (10.0w%). Compared to CS, the antibacterial activity of GT-CS is improved significantly, approaching the pure gentamicin. It should be noted that the antimicrobic mechanism may not be the target-specific interactions but the nonspecific interactions with the bacterial membrane as shown by scanning electron microscope. To sum up, GT-CS is a superior antimicrobial with good solubility.